Effect of Guhong Injection Combined with Ticagrelor in the Treatment of Acute Myocardial Infarction
Objective To investigate the clinical effect of Guhong injection combined with ticagrelor in the treatment of Acute myocardial infarction(AMI).Methods A total of 92 patients with AMI treated in Jiaozuo Coal Industry(Group)Co.,Ltd.Central Hospital from January 2021 to December 2022 were selected and divided into study group and control group with 46 cases each by random number table method.Both groups received conventional drug treatment,the control group received ticagrelor,and study group received grain Guhong injection on the basis of control group.Both groups were treated continuously for 2 weeks.The clinical efficacy,cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)],hemorheology indexes(HCT),whole blood low tangential viscosity(LBV),plasma viscosity(PV),whole blood high tangential viscosity(HBV),protein kinase(PKG)signaling pathway related indicators[cyclic guanosine phosphate(cGMP),PKG]and the incidence of adverse reactions before and after treatment were compared between the two groups.Results The total clinical effective rate of the research group was higher than that of the control group(P＜0.05),LVEF,cGMP,and PKG were higher than those of the control group,and LVESD,LVEDD,HCT,HBV,PV,and LBV were lower than those of the control group(P＜0.05).There was no statistically difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of Guhong injection and Grello has a definite effect in the treatment of AMI,which can promote the improvement of heart function and hemorheology,and has a certain degree of safety.
Guhong injectionticagreloracute myocardial infarctionprotein kinase signaling pathwaycardiac function
万方数据
维普
