Effects of Staging Acupuncture Based on"Flushing for a Sea of Blood"on IVF-ET Assisted Pregnancy Outcome,Sex Hormones and Endometrial Blood Flow Parameters in Patients with Kidney Deficiency Phlegm-Dampness Type Polycystic Ovary Syndrome
Objective To evaluate the effects of staging acupuncture based on"flushing for a sea of blood"on in vitro fertilization-embryo transfer(IVF-ET)assisted pregnancy outcome,sex hormones and endometrial blood flow parameters in patients with kidney deficiency phlegm-dampness type polycystic ovary syndrome.Methods From January 2020 to January 2022,60 patients with kidney deficiency phlegm-dampness-type polycystic ovary syndrome were admitted to the Department of Reproductive Medicine of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine.They were divided into the control group(30 cases)and the combined group(30 cases),using random number table method.The control group received simple follicular phase long protocol ovulation induction,followed by transvaginal oocyte retrieval under the guidance of vaginal B ultrasound,and high-quality embryos were transplanted 72 h after ovulation.On the basis of the control group,the combined group was given staging acupuncture based on"flushing for a sea of blood"until eggs were taken,and the pregnancy outcome was observed at 10 month after IVF-ET follow-up.The two groups of conditions of embryo acquisition and implantation,IVF-ET assisted pregnancy outcome,endometrial blood flow parameters,thickness,type,sex hormones,scores of traditional Chinese medicine syndrome before and after treatment,and adverse reactions during treatment were compared.Results The number of eggs,high quality embryo rate,embryo implantation rate,clinical pregnancy rate,biochemical pregnancy rate and live birth rate in the combination group were higher(P＜0.05).Compared with before treatment,blood flow pulsation index(PI),blood flow resistance index(RI),serum level of testosterone(T)of the two groups decreased after treatment,and the combined group was lower(P＜0.05).Compared with before treatment,after treatment,endometrial thickness,endometrial type A ratio,serum levels of progesterone(P)and estradiol(E2)increased in the two groups,and higher in the combination group(P＜0.05).There was no diffrence in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The treatment of kidney deficiency phlegm-dampness polycystic ovary syndrome by staging acupuncture and moxibustion based on"the sea of blood"could alleviate traditional Chinese medicine symptoms,regulate sex hormones and endometrial blood flow parameters,improve endometrial morphology,promote embryo obtaining and implantation in IVF-ET,and ultimately optimize the outcome of pregnancy assisted by IVF-ET.
polycystic ovary syndromekidney deficiency phlegm-dampness typestaging acupuncturevitro fertilization-embryo transfer
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