Efficacy and Safety of Voriconazole in the Prevention and Treatment of Invasive Fungal Infections in Children:A Systematic Review and Meta-Analysis
Objective To systematically evaluate the efficacy and safety of voriconazole(VRC)in the prevention and treatment of invasive fungal infections(IFI)in children and to provide evidence for the clinical prophylactic and therapeutic use of VRC.Methods PubMed,Embase,Cochrane Library,Wanfang database,and China Knowledge Network were systematically searched to include all relevant clinical studies on the application of VRC for the prevention and treatment of IFI in children.The search period was from the establishment of the database to May 2023.Stata 14.0 software was used to perform meta-analysis on the efficacy and safety of drug administration.Results A total of 15 relevant studies were included,10 of which were therapeutically administered and 5 were prophylactically administered.The results showed that VRC was more effective than the control group in the treatment of IFI(OR=2.05,95％CI:1.10-3.82,P=0.003),and its incidence of adverse effects was lower than that of amphotericin B and higher than that of caspofungin,but the difference was not statistically significant(P＞0.05).Prophylactic administration of VRC was not associated with a reduction in the incidence of IFI in children(OR=0.57,95％CI:0.19-1.71,P=0.083)and did not increase the incidence of adverse effects in children(OR=0.70,95％CI:0.16-3.09,P=0.015).Conclusion VRC is effective and relatively safe for the treatment of IFI in children compared with other antifungal agents.Prophylactic application of VRC is not significantly associated with the lower incidence of IFI in children.
万方数据
维普
