Influence of Peritoneal Dialysis Combined with Hemodialysis on Renal Fibrosis Status and Vascular and Valve Calcification in Patients with Uremia
Objective To explore the influence of peritoneal dialysis combined with hemodialysis on renal fibrosis status and vascular and valve calcification in patients with uremia.Methods Retrospective analysis of clinical data of 112 uremia patients admitted to Luohe Central Hospital from January 2021 to January 2022.According to the dialysis method,it was divided into peritoneal dialysis group(36 cases),hemodialysis group(44 patients)and combined dialysis group(32 cases).Dialysis adequacy[urea clearance index(Kt/V)],renal function indicators[blood urea nitrogen(BUN),serum creatinine(SCr)],renal fibrosis indicators[connective tissue growth factor(CTGF),bone morphogenetic protein-7(BMP-7)],calcium-phosphorus metabolism indicators[blood calcium,blood phosphorus,intact parathyroid hormone(iPTH)],carotid intima-media thickness(CIMT)and incidence rate of vascular calcification before treatment and after 12 months of treatment and occurrence of adverse reactions during treatment were compared between the two groups.Results The Kt/V in hemodialysis group and combined dialysis group were higher than peritoneal dialysis group,and the BUN and SCr levels of patients were lower than those in peritoneal dialysis group(P＜0.05).After treatment,the levels of CTGF,blood calcium,blood phosphorus,iPTH,CIMT and incidence rate of carotid artery calcification in hemodialysis group were higher than those in peritoneal dialysis group and combined dialysis group,while the BMP-7 level was lower than that in peritoneal dialysis group and combined dialysis group(P＜0.05).The incidence rates of pulmonary hypertension and congestive heart failure in hemodialysis group were higher compared with those in peritoneal dialysis group and combined dialysis group(P＜0.05).Conclusion Compared with single dialysis,peritoneal dialysis combined with hemodialysis has a better effect on improving the calcium-phosphorus metabolism,renal fibrosis and carotid artery calcification in patients with uremia,and the latter one has fewer vascular related complications and higher safety.
万方数据
维普
