Influencing Factors of Early Neurological Deterioration in Patients with Acute Cerebral Infarction After Intravenous Thrombolysis
Objective To investigate the influencing factors of early neurological deterioration(END)in patients with acute cerebral infarction after intravenous thrombolysis.Methods A total of 174 patients with acute cerebral infarction who were treated with alteplase intravenous thrombolysis within 4.5 hours from March 2018 to March 2022 in Kaifeng Central Hospital were retrospectively selected as the study objects.According to the outcome of thrombolysis,they were divided into an END group(46 cases)and a non END group(128 cases).General data such as gender,age,past history and serum albumin level and leukocyte count level of the two groups were analyzed,and the correlation between the END of intravenous thrombolysis and serum albumin level and leukocyte count level of the patients with acute cerebral infarction was analyzed by 2-element logistic regression.Results There was no significant difference in general data between the two groups(P＞0.05).There were significant differences in serum albumin and white blood cell count between two groups(P＜0.05).The results of 2-element logistic regression analysis showed that the serum albumin level was positively correlated with the END of intravenous thrombolysis,while the white blood cell count level was negatively correlated with the END of intravenous thrombolysis,with statistical significance(P＜0.05).Conclusion The decrease of serum albumin and the increase of white blood cell count level in patients with intravenous thrombolytic therapy increase the risk of intravenous thrombolytic END.The decrease of serum albumin and white blood cell count level are independent risk factors for intravenous thrombolytic END.It is necessary to strengthen the detection and intervention of serum albumin and white blood cell count level in patients with intravenous thrombolytic therapy to reduce the occurrence of intravenous thrombolytic END.
万方数据
维普
