Infection,Distribution Characteristics of Pathogens and Drug Resistance in Patients After Kidney Transplantation
Objective To explore infection,distribution characteristics of pathogens and drug resistance in patients after kidney transplantation.Methods Retrospective analysis of clinical data of 172 kidney transplant patients admitted to Zhengzhou Seventh People's Hospital from February 2021 to February 2023,divided into infection group(54 cases)and non infection group(118 cases)based on whether postoperative infection occurred.The time and type of infection of the patient are recorded.Isolate and identify pathogens through a fully automated microbiological analyzer,and conduct drug sensitivity tests using paper diffusion method.Results After kidney transplantation,common pulmonary infections(51.85％)and urinary tract infections(31.48％)were observed in patients,with a peak of infection occurring 2-6 months after surgery.The main pathogens were Gram-negative bacteria(58.33％),mainly including Pseudomonas aeruginosa(19.44％),Klebsiella pneumoniae(16.67％)and Staphylococcus epidermoides(15.28％).The resistance rates of main Gram-negative bacteria were high to cefazolin,levofloxacin,cefepime,cefotaxime,ceftazidime and ampicillin,and their sensitivity was also high to imipenem and meropenem.The main Gram-positive bacteria were sensitive to teicoplanin,vancomycin,compound sulfamethoxazole and sulperazone,and their resistance was high to erythromycin and clindamycin.Conclusion Clinically,symptomatic medication can be administered based on the distribution and drug resistance of pathogenic bacteria after kidney transplantation in hospitals,taking into account the actual situation of patients,in order to improve treatment efficiency,especially during the critical period of 2-6 months after surgery.
kidney transplantationinfectiondistribution of pathogendrug resistance
万方数据
维普
