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益气养阴散结法结合PC方案应用于晚期肺癌患者的效果

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目的 分析益气养阴散结法结合PC方案应用于晚期肺癌患者中的效果.方法 对2021年1月至2022年12月在许昌医院就诊的100例晚期肺癌患者病历资料进行回顾性分析,采用PC方案的为对照组,行益气养阴散结法结合PC方案的为观察组,比较两组临床疗效、肿瘤标志物水平[糖类抗原199(CA199)、糖类抗原125(CA125)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)]、炎症因子水平[肿瘤坏死因子-α(TNF-α)、白介素-10(IL-10)、超敏C反应蛋白(hs-CRP)]、安全性.结果 观察组的总缓解率比对照组高(P<0.05);治疗前,两组CA199、CA125、CEA、NSE水平差异无统计学意义(P>0.05);治疗后,两组各指标较治疗前均降低,且观察组比对照组低(P<0.05);治疗前,两组TNF-α、IL-10、hs-CRP水平差异无统计学意义(P>0.05);治疗后,两组各指标均降低,且观察组比对照组低(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05).结论 对晚期肺癌患者,采用益气养阴散结法结合PC方案的效果更好,还能降低肿瘤标志物水平,且安全性高.
Application Effects of Yiqi Yangyin Sanjie Method Combined with PC Regimen in Patients with Advanced Lung Cancer
Objective To analyze the application effects of Yiqi Yangyin Sanjie method combined with PC regimen in patients with advanced lung cancer.Methods A retrospective analysis was conducted on the medical records of 100 patients with advanced lung cancer who were treated at Xuchang Hospital from January 2021 to December 2022.The PC regimen was used as the control group,while the combination of Yiqi Yangyin Sanjie method and PC regimen was used as the observation group.The clinical efficacy,tumor marker levels[carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),neuron specific enolase(NSE)],inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),hypersensitive C-reactive protein(hs-CRP)],and safety of the two groups were compared.Results The total remission rate of the observation group was higher than that of the control group(P<0.05).Before treatment,there was no difference in the levels of CA199,CA125,CEA,and NSE between the two groups(P>0.05).After treatment,all indicators in both groups decreased compared to before treatment,and the observation group was lower than the control group(P<0.05).Before treatment,There were no differences in the levels of TNF-α,IL-10,and hs-CRP between the two groups(P>0.05).After treatment,all indicators in both groups decreased,and the observation group was lower than the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion For patients with advanced lung cancer,the combination of Yiqi Yangyin Sanjie method and PC regimen has a better therapeutic effect,can also reduce the level of tumor markers,and has high safety.

lung cancerYiqi Yangyin Sanjie methodPC regimentumor marker levels

徐跃峰、高永辉、刘艳娜

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许昌医院肿瘤内科,河南许昌 461000

肺癌 益气养阴散结法 PC方案 肿瘤标志物水平

2024

河南医学研究
河南省医学科学院

河南医学研究

影响因子:0.979
ISSN:1004-437X
年,卷(期):2024.33(22)