Risk Factors of Severe Hand,Foot and Mouth Disease Complicated with Neurogenic Pulmonary Edema
Objective To analyze the influencing factors of neurogenic pulmonary edema(NPE)in children with severe hand,foot and mouth disease(HFMD),and explore the laboratory indexes for early prediction of NPE.Methods From June 2019 to June 2022,a total of 184 children with severe HFMD admitted to ICU of Children's Hospital Affiliated to Zhengzhou University were selected.According to the condition,they were divided into severe HFMD complicated with NPE group and severe HFMD without NPE group.The clinical manifestations,blood routine,C-reactive protein,blood glucose,neuron specific enolase(NSE),S-100B protein,N-terminal pro-brain natriuretic peptide(NT-proBNP)and other laboratory results of the two groups were recorded.The data were analyzed by SPSS 21.0 software,and the clinical data of the two groups were compared by single factor analysis.Logistic multiple regression analysis was carried out on the possible influencing factors.Results Among the 184 children with severe HFMD,there were 163 children with severe HFMD without NPE and 21 children with severe HFMD with NPE.Univariate analysis showed that there were significant differences in age,white blood cell level and NT-proBNP level between the two groups(P＜0.05).Multivariate logistic regression analysis showed that NT-proBNP level was an independent influencing factor for severe HFMD complicated with NPE.Receive operating characteristic(ROC)curve analysis showed that when the cutoff value of NT-proBNP was 758.9 ng·L-1,the sensitivity was 85.7％and the specificity was 92.6％,which had the highest diagnostic efficiency for severe HFMD with NPE.Conclusion Serum NT-proBNP level is an independent influencing factor of severe HFMD complicated with NPE,and its detection is helpful for early identification of severe HFMD complicated with NPE.
severe hand,foot and mouth diseaseneurogenic pulmonary edemarisk factorN-terminal pro-brain natriuretic peptide
万方数据
维普
