Value of Preoperative Peripheral Blood Inflammatory Markers Combined with HE4 in the Diagnosis of Serous Ovarian Cancer
Objective To explore the diagnostic value of preoperative peripheral blood inflammatory markers such as platelet to lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR)combined with human epididymal protein 4(HE4)for serous ovarian cancer(SOC)and their correlation with clinical and pathological features.Methods A retrospective analysis was conducted on 92 patients with SOC admitted to the Third Affiliated Hospital of Zhengzhou University from August 2021 to August 2023 as the SOC group,and 88 patients with benign ovarian tumors during the same period were selected as the control group.Laboratory data on preoperative PLR,NLR,MLR,and HE4 levels,as well as postoperative pathological data of patients in the SOC group,were collected from both groups.The expression differences of PLR,NLR,MLR,and HE4 were compared between two groups of patients before surgery,the diagnostic value of PLR,NLR,MLR combined with HE4 for SOC were evaluated using receiver operating(ROC)curve,and the relationship was analyzed between PLR,NLR,MLR and clinical pathological features.Results Compared with the control group,the levels of PLR,NLR,MLR,and HE4 were increased in the SOC group,and the difference was statistically significant(P＜0.05).The area under the ROC curve of PLR,NLR,MLR,HE4,and the above four combined detection for the diagnosis of SOC were 0.693,0.733,0.759,0.937,and 0.954,respectively,with sensitivities of 72.8％,70.7％,84.8％,79.3％,and 80.4％,and specificity of 61.2％,69.4％,52.9％,96.5％,and 95.3％,respectively.PLR was related to FIGO staging,NLR was related to FIGO staging and lymph node metastasis,and MLR was related to FIGO staging and tissue differentiation.Conclusion Preoperative NLR,PLR,and MLR are closely related to the pathological staging,tissue differentiation,and lymph node metastasis of serous ovarian cancer.Preoperative peripheral blood inflammatory markers combined with HE4 detection can serve as important reference indicators in the diagnosis of SOC and provide reference information for clinical diagnosis and treatment.
serous ovarian cancerplatelet to lymphocyte rationeutrophil to lymphocyte ratiomonocyte to lymphocyte ratiopathological feature
万方数据
维普
