Construction of Risk Factor Prediction Model for Liver Function Insufficiency in Patients with Primary Liver Cancer After Interventional Therapy
Objective To analyze the risk factors of liver function insufficiency in patients with primary liver cancer after interventional therapy and build a prediction model.Methods From May 2018 to December 2022,108 patients with primary liver cancer who received interventional therapy and liver function insufficiency were included in the study group,and 112 patients who did not have liver function insufficiency during the other period were included in the control group.Clinical data of these patients were retrospectively collected.The risk factors of liver function insufficiency in patients with primary liver cancer after interventional therapy were analyzed by single factor analysis and multivariate analysis,the prediction model was established,and the receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of the prediction model for liver function insufficiency in patients with primary liver cancer after interventional therapy.Results Multivariate logistic analysis showed that age＞60 years old,pathological type of liver cancer giant type,liver function classification grade B,number of interventional therapy＞2 times,complicated with cirrhosis,severe anemia,and complicated with hypoproteinemia were risk factors for liver function insufficiency after interventional therapy in patients with primary liver cancer(P＜0.05).Incorporate the above factors into the forecast model.Patients with liver function insufficiency after interventional therapy were included as positive,while patients with non-compensatory liver function insufficiency after interventional therapy were included as negative.ROC curve for predicting the occurrence of liver function insufficiency in patients with primary liver cancer after interventional therapy was drawn according to the prediction model.The results showed that when logit(P)＞13.67,area under curve(AUC)was 0.903,the diagnostic sensitivity was 88.77％,the specificity was 83.12％.Conclusion The occurrence of liver function insufficiency in patients with primary liver cancer after interventional therapy was closely related to many factors,the established prediction model had high value in predicting the occurrence of liver function insufficiency in patients with primary liver cancer after interventional therapy,and could provide basis for screening high-risk patients and formulating clinical prevention and treatment strategies.
primary liver cancerliver function insufficiencyrisk factorsmodelreceiver operating characteristic
万方数据
维普
