Serum Levels of HGF,Flt3L,MIP-1α in Patients with Acute Myeloid Leukemia and Its Relationship with Prognosis
Objective To investigate the serum levels of hepatocyte growth factor(HGF),FMS-like tyrosine kinase 3 ligand(Flt3L),and macrophage inflammatory protein-1α in patients with macrophage inflammatory protein 1(MIP-1)and their relationship with prognosis.Methods The clinical data of 102 patients with acute myeloid leukemia admitted to the First Affiliated Hospital of Henan University of Science and Technology from May 2020 to January 2022 were retrospectively selected as the case group.All patients were treated with standardized treatment for 8 weeks,and were followed up for 1 year.The selected patients were divided into non remission group(28 cases),the partial remission group(45 cases),and the complete remission group(29 cases)according to the short term efficacy,the selected patients were divided into the poor prognosis group(34 cases)and the good prognosis group(68 cases)according to the long-term prognosis,with an additional 115 healthy volunteers admitted during the same period as the control group.The serum levels of HGF,Flt3L,and MIP-1α in the case group and the control group,in patients with acute myeloid leukemia before and after 8 weeks of treatment,as well as in patients with different short term efficacy and long-term prognosis were compared,draw receiver operating characteristic(ROC)curve and the serum HGF,Flt3L,MIP-1α for the predictive value of poor long-term prognosis in patients with acute myeloid leukemia were analyzed.Results Serum levels of HGF and MIP-1 α in the case group were higher than the control group(P＜0.05);the serum level of Flt3L was lower than the control group(P＜0.05).After 8 weeks of treatment,serum levels of HGF and MIP-1 α in patients with acute myeloid leukemia were lower than before treatment(P＜0.05),the serum level of Flt3 L was higher than before treatment(P＜0.05).Serum levels of HGF and MIP-1αin the non remission group were higher than the partial remission group and the complete remission group(P＜0.05),and the partial remission group was higher than the complete remission group(P＜0.05);the level of serum Flt3 L in the non remission group was lower than the partial remission group and the complete remission group(P＜0.05),and the partial remission group was lower than the complete remission group(P＜0.05).Serum levels of HGF and MIP-1 α in the poor prognosis group were higher than the good prognosis group(P＜0.05),the serum level of Flt3L was lower than the good prognosis group(P＜0.05).The area under the curve(AUC)value of the combined detection of serum HGF,Flt3L,and MIP-1α for diagnosing poor long-term prognosis in patients with acute myeloid leukemia was 0.937,which was higher than serum HGF,Flt3L,and MIP-1α individually tested(0.817,0.713,0.801,P＜0.05).Conclusion The serum levels of HGF and MIP-1α are highly expressed in patients with acute myeloid leukemia,while the serum level of Flt3L is low.The changes in these levels have a certain guiding role in evaluating the short term efficacy and long-term prognosis of acute myeloid leukemia patients,and the combined detection of the three has higher diagnostic value for poor long-term prognosis in acute myeloid leukemia patients.
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