Relationship Between Serum SP-D Expression and Prognosis of Antiviral Therapy in Children with Respiratory Syncytial Virus Pneumonia
Objective To investigate the relationship between the expression of serum surfactant protein-D(SP-D)and the prognosis of antiviral therapy in children with respiratory syncytial virus pneumonia.Methods A prospective study was conducted on children with respiratory syncytial virus pneumonia admitted to People's Hospital of Zhengzhou from January 2021 to March 2023.All children were treated with antiviral therapy,and serum SP-D levels were measured before and after treatment.The prognosis of the children after treatment was observed and divided into good and poor prognosis groups.The relationship between serum SP-D levels and prognosis was analyzed.Results After 7 days of antiviral therapy,69 out of 88 children with respiratory syncytial virus pneumonia had a good prognosis(78.41％)and 19 out of them had a poor prognosis(21.59％).The average serum SP-D levels before and after treatment in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant(P＜0.05).The results of point two column correlation analysis showed that the pre treatment serum SP-D level in children with respiratory syncytial virus pneumonia was positively correlated with the prognosis(r＞0,P＜0.05).The results of receiver operating characteristic showed that the area under the curve of serum SP-D level before treatment to predict the prognosis of children with respiratory syncytial virus pneumonia was＞0.7,which had certain evaluation value.Conclusion The serum SP-D level before antiviral therapy in children with respiratory syncytial virus pneumonia is related to prognosis,and clinical detection of serum SP-D level can predict prognosis.
万方数据
维普
