Effects of Sentinel Lymph Node Biopsy During Modified Radical Mastectomy on Shoulder Joint Function and Postoperative Complications in Elderly Patients with Breast Cancer
Objective To investigate the effects of modified radical mastectomy combined with sentinel lymph node biopsy on shoulder joint function and postoperative complications in elderly patients with breast cancer.Methods A total of 100 cases of elderly breast cancer patients in General Hospital of Pingmei Shenma Medical Group were retrospectively selected as research subjects from April 2019 to April 2022,and were divided into control group and observation group according to the treatment plan,with 50 cases in each group.The control group was treated with modified radical mastectomy for breast cancer,and the observation group was treated with modified radical mastectomy+sentinel lymph node biopsy for breast cancer.Sentinel lymph nodes were counted.The sentinely lymph node status,stress indexes[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and tumor markers[carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153)],bilated upper arm circumference,shoulder function score and 1 a recurrence and survival were statistically compared between the two groups before and after surgery.Bilateral upper arm circumference and shoulder joint function scores were compared between the two groups before and 1 month after surgery.The recurrence free survival was compared between the two groups 1 year after operation.Results The operation time of the observation group was longer than that of the control group,the hospital stay was shorter than that of the control group,and the intraoperative bleeding and postoperative complication rates were lower than those of the control group(P＜0.05).The levels of serum CRP,IL-6 and TNF-α were firstly increased and then decreased(P＜0.05),but there was no statistical significance between the two groups(P＞0.05).The levels of serum CA125,CEA and CA153 in observation group were lower than those in control group(P＜0.05).The difference of upper arm circumference in the observation group was lower than that in the control group,and the shoulder joint function score was higher than that in the control group(P＜0.05).There was no significant difference in recurrence-free survival rate and survival time at 1 year after surgery between the two groups(P＞0.05).Conclusion The combined treatment of modified radical mastectomy and sentinel lymph node biopsy in elderly patients with breast cancer can reduce the incidence of postoperative complications,reduce the degree of shoulder joint function impairment,help to preserve the upper limb function of patients,relieve the degree of body stress,inhibit tumor metastasis,and have no significant impact on relapse-free survival.
万方数据
维普
