Relationship Between Serum IL-10,VEGF Levels and Prognosis of Patients with Uterine Cervical Carcinoma After Surgical
Objective To observe the correlation between the levels of serum interleukin-10(IL-10),vascular endothelial growth factor(VEGF)and the prognosis of patients with uterine cervical carcinoma(UCC)after surgical treatment.Methods A total of 126 patients with UCC treated in Zhumadian Maternal and Child Health Hospital from June 2018 to June 2019 were prospectively selected as the research subjects,and all patients underwent serum IL-10 and VEGF levels testing upon admission and underwent modified radical hysterectomy treatment.They were followed up for 2 years to observe the recurrence during the follow-up period.The recurrence of the patients was taken as a prognostic indicator and grouped into groups.Recurrent patients were included in the group with poor prognosis,while non recurrent patients were included in the group with good prognosis.The general data of patients were asked and recorded,and the relationship between serum IL-10 and VEGF levels and the prognosis of UCC patients after surgical treatment was analyzed.Results All 126 patients were followed up for 2 years,with 26 cases experiencing recurrence during the follow-up period,with a recurrence rate of 20.63％(26/126).The proportion of stage Ⅱand adenocarcinoma in the clinical staging of the poor prognosis group was higher than that of the good prognosis group.The serum IL-10 and VEGF levels at admission were higher than those of the good prognosis group(P＜0.05).The results of logistic regression analysis showed that the overexpression of serum IL-10 and VEGF at admission,pathological classification as adenocarcinoma,and high clinical staging of UCC patients were associated with postoperative prognosis,and might be risk factors for poor prognosis(OR＞1,P＜0.05).The serum IL-10 and VEGF levels alone and in combination predict the AUC of surgical treatment prognosis in UCC patients,which were 0.764,0.757,and 0.816,respectively,with values greater than 0.70,indicating high predictive value.Conclusion Overexpression of serum IL-10 and VEGF is associated with poor prognosis after surgical treatment in UCC patients.The risk of poor prognosis in UCC patients can be predicted by the levels of serum IL-10 and VEGF at admission.
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