Changes of Levels of Serum sCD40L,FGF23,Hcy,hs-CRP and Their Relationship with Carotid Artery Plaque in Patients with Cerebral Embolism
Objective To investigate the changes of levels of serum soluble CD40 ligand(sCD40L),fibroblast growth factor 23(FGF23),homocysteamine(Hcy),hypersensitive C-reactive protein(hs-CRP)in patients with cerebral embolism and their relationship with carotid artery plaque.Methods A total of 110 cases of cerebral embolism patients with carotid artery plaque admitted to Anyang Third People's Hospital from January 2021 to December 2022 were selected as the cerebral embolism group,119 cases of healthy physical examination subjects who underwent physical examination in hospital during the same period were selected as the control group,and the general data of the two groups were analyzed.Levels of serum sCD40L,FGF23,Hey,hs-CRP,carotid ultrasound results and levels of serum sCD40L,FGF23,Hcy,hs-CRP in patients with cerebral embolism with different carotid plaque stability were compared between the two groups.Pearson correlation was used to analyze the correlation between serum levels of sCD40L,FGF23,Hcy,hs-CRP and carotid artery plaque in patients with cerebral embolism.Results The serum levels of sCD40L,FGF23,Hcy,hs-CRP,carotid artery plaque number,plaque evaluation and carotid intima-media thickness(IMT)in the cerebral embolism group were higher than those in the control group(P＜0.05).The clear levels of sCD40L,FGF23,Hcy and hs-CRP in the plaque unstable group were higher than those in the plaque stable group(P＜0.05).Pearson correlation analysis showed that serum sCD40L,FGF23,Hcy and hs-CRP were significantly positively correlated with carotid plaque number,score of plaque and IMT in patients with cerebral embolism(r＞0,P＜0.05).Conclusion Serum sCD40L,FGF23,Hcy,hs-CRP were closely related to the occurrence of cerebral embolism and carotid artery plaque,and could be used for the diagnosis of unstable plaque,which had positive significance for the prediction of the occurrence of cerebral embolism.
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