Clinical Effect of Xuebijing Injection in the Adjuvant Treatment of Septic Shock and Its Influence on Inflammatory Pathway
Objective To explore the clinical effect and action mechanism of Xuebijing Injection in the adjuvant treatment of septic shock.Methods A total of 140 patients with septic shock in the Anyang People's Hospital were enrolled from January 2020 to December 2022.According to random number table method,they were divided into control group and observation group.The control group was given continuous renal replacement treatment,anti-infection,assisted ventilation,while observation group was additionally treated with Xuebijing Injection.The hospitalization situations,28 days mortality,scores of acute physiological and chronic health evaluation Ⅱ(APACHE Ⅱ)and sequential organ failure assessment(SOFA),serum lactic acid(LA),tumor necrosis factor α(TNF-α),interleukin 6(IL-6),cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),cardiac index(CI)],interleukin-1β(IL-1β),Toll-like receptor 4(TLR4)and nuclear factor-κB(NF-κB)mRNA were compared between the two groups before and after treatment.Results After treatment,there was no significant difference in stay time in ICU,total hospitalization time,mechanical ventilation time or 28 days mortality between the two groups(P＞0.05).After treatment,APACHE Ⅱ and SOFA scores in observation group were lower than those in control group(P＜0.05),levels of LA,TNF-α and IL-6 were lower than those in control group(P＜0.05),LVEF,LVESD,LVEDD and CI were higher than those in control group(P＜0.05),IL-1β,TLR4 and NF-κB mRNA in macrophages were lower than those in control group(P＜0.05).Conclusion Xuebijing adjuvant therapy can relieve conditions,improve cardiac function and reduce inflammatory response by regulating NF-κB signaling pathway.
万方数据
维普
