Expression and Significance of Silence Information Regulator 1 in Placenta of Fetal Growth Restraction Patients
Objective To study the expression of silence information regulator(SIRT)1 in fetal growth restraction(FGR)placental tissue,and to explore the significance in the occurrence of FGR.Methods A total of 100 cases of FGR placental tissue delivered from January 2017 to December 2021 in Zhengzhou Maternal and Child Health Hospital were selected as the FGR group,and 100 cases of non-FGR placental tissue were selected as the control group.They were not associated with other diseases or complications.FGR group was divided into early-onset FGR(35 cases)and late-onset FGR(65 cases)according to the time of diagnosis.Immunohistochemical method was used to determine the expression of SIRT1 in placenta.Results Gestational week,birth length,birth weight,placental weight and Apgar 1 minute score in FGR group were all lower than those in control group(P＜0.05).SIRT1 was mainly expressed in cytotrophoblast cells and syncytiotrophoblast nuclei.The ratio of SIRT1 positive cells,average optical density and high expression rate of placental tissue in FGR group were lower than those in control group(P＜0.05).The ratio of SIRT1 positive cells,average optical density value and high expression rate in placental tissues with early-onset FGR were lower than those with late-onset FGR(P＜0.05).The expression of SIRT1 in placental tissues was positively correlated with gestational weeks,birth length,birth weight and placental weight of newborns(P＜0.05).Conclusion SIRT1 is low expressed in placenta of FGR patients,and SIRT1 may be involved in the pathogenesis of FGR.
fetal growth restractionsilent information regulatorplacentaimmunohistochemistry
万方数据
维普
