Relationship Between Expressions of Vascular Cell Adhesion Molecule-1 and P14Arf Protein and Tumor Malignancy Degree and Postoperative Recurrence in Patients with Brain Glioma
Objective To explore the relationship between expressions of vascular cell adhesion molecule-1(VCAM-1)and P14Arf protein and tumor malignancy degree and postoperative recurrence in patients with brain glioma.Methods The tissue specimens of 102 patients with brain glioma confirmed by pathological examination(brain glioma group)and normal cerebral tissues of patients undergoing internal decompression due to craniocerebral injury(control group)were collected.The expressions of VCAM-1 and P14Arf protein in blood vessels were detected by immunohistochemistry,and the differences in expressions were compared among different grades.According to the recurrence at 6 months after surgery,the patients were divided into recurrence group and non-recurrence group.The expressions of VCAM-1 and P14Arf protein in brain glioma tissues were compared between both groups,and the relationship between the expression of each protein and clinical pathology was analyzed.Results The differences in family history of brain glioma,exposure history of naphtha and diesel oil,exposure history of radiation or electromagnetic field,metal lead exposure history,pesticide exposure history and positive rates of VCAM-1 and P14Arf protein were statistically significant between brain glioma group and control group(P＜0.05),but there were no statistically significant differences in gender,age,smoking and drinking(P＞0.05).With the increase of malignancy degree of brain glioma,the high expression rate of VCAM-1 was gradually increased while the high expression rate of P14Arf protein was gradually decreased,and the high expression levels of VCAM-1 and P14ARF protein in patients with grade Ⅲ or Ⅳ brain glioma were statistically different compared with those in patients with grade Ⅰ or Ⅱ brain glioma(P＜0.05),but there were no statistical differences in the expressions of VCAM-1 and P14Arf protein between grade Ⅰ patients and grade Ⅱ patients(P＞0.05).The expressions of VCAM-1 and P14Arf protein among patients with different tissue differentiation degrees and Karnofsky scores were significantly different(P＜0.05).The high expression rate of VCAM-1 and low expression rate of P14Arf protein in recurrence group were higher than those in non-recurrence group(P＜0.05).Conclusion The expression levels of VCAM-1 and P14Arf protein are related to the progression and survival prognosis of brain glioma,and can be used as reference indicators for clinical diagnosis and treatment.
brain gliomaserum vascular cell adhesion molecule-1P14Arf protein
万方数据
维普
