Distribution and Drug Resistance of Carbapenem-Resistant Enterobacteriales in A Hospital from 2020 to 2022
Objective To analyze the detection and drug resistance of Carbapenem-resistant Enterobacteriales in Luohe Central Hospital from 2020 to 2022,in order to guide the rational use of antibiotics and hospital infection prevention and control.Methods A retrospective analysis was conducted on all Enterobacteriaceae bacteria isolated and cultured from patient specimens in Luohe Central Hospital from January 2020 to December 2022,using WHONET 5.6 software for statistics and analysis.Results From 2020 to 2022,a total of 2 540 strains of Enterobacteriaceae bacteria were isolated from Luohe Central Hospital,among which 292 strains were Carbapenem-resistant Enterobacteriales,with a detection rate of 11.50％.The detection rates of Carbapenem-resistant Enterobacteriales from 2020 to 2022 were 11.87％,10.92％,and 11.69％,respectively.The three most frequently detected types of Carbapenem-resistant Enterobacteriales were Klebsiella pneumoniae(153 strains,accounting for 52.4％),Enterobacter cloacae(48 strains,16.44％),and Escherichia coli(33 strains,11.30％).The top three sources of specimens were sputum(181 strains,61.99％),urine(37 strains,12.67％),and blood(15 strains,5.14％).The departments with the most frequent distribution of Carbapenem-resistant Enterobacteriales were neurosurgery(99 strains,33.90％),followed by ICU(53 strains,18.15％).Antimicrobial susceptibility results showed that Carbapenem-resistant Enterobacteriales were highly resistant to conventional drugs,with significantly higher resistance rates than Enterobacteriales bacteria.From 2020 to 2022,the resistance rates of Carbapenem-resistant Enterobacteriales to some drugs showed a downward trend.Conclusion The detection rate of Carbapenem-resistant Enterobacteriales in Luohe Central Hospital is higher than the national level,but it is showing a downward trend.Carbapenem-resistant Enterobacteriales have high drug resistance,and the resistance rates to some commonly used antibiotics have decreased.The main Enterobacteriales bacteria are Klebsiella pneumoniae,Enterobacter cloacae,and Escherichia coli,with the most common site of infection being the lower respiratory tract.
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