医药论坛杂志2015，Vol.36Issue(2) ：30-33.

不同年龄段食管癌患者临床病理特点和生存状况研究

Clinicopathologic characteristics and prognosis of esophagus cancer patients between different age groups

王志永 周强 柴雅枚
医药论坛杂志2015，Vol.36Issue(2) ：30-33.
✕
  • NETL
  • NSTL
  • 维普
  • 万方数据

不同年龄段食管癌患者临床病理特点和生存状况研究

Clinicopathologic characteristics and prognosis of esophagus cancer patients between different age groups

王志永 1周强 2柴雅枚3
扫码查看

作者信息

  • 1. 郑州市第一人民医院,郑州450000
  • 2. 郑州市儿童医院
  • 3. 河南省胸科医院
  • 折叠

摘要

目的 探讨不同年龄段食管癌患者临床病理特点以及生存状况的差异.方法 426例食管癌患者根据患者的年龄进行分组,＞45岁的患者作为中老年组(356例),≤45岁的患者作为分为青年组(70例).收集患者的临床资料,分析其临床病理特点以及预后.结果 所有患者的5年和10年生存率分别为35.2％ (150/426)和26.3％(112/426),青年组和中老年组的5年生存率(37.1％vs.34.8％,P＞0.05)、10年生存率(30.0％vs.25.6％,P＞0.05)差异无显著差异.但青年组患者TNM分期的Ⅲ期人数比例(51.4％,36/70)高于中老年组(36.5％,130/356),x2=5.469,P＜0.05.Kaplan-Meier法单因素分析,患者淋巴结无转移、淋巴结转移区域数少、分化程度高的食管癌患者预后较好(P＜0.05).Cox回归分析,淋巴结转移(x2=8.110,P＜0.05)、淋巴结转移区域数(x2=9.992,P=0.002)、分化程度(x2=4.468,P＜0.05)是食管癌患者预后的影响因素.结论 虽然青年患者食管癌的病理分期较晚,但其预后与中老年患者无明显差异,淋巴结转移、淋巴结转移区域越多、分化程度低不利于食管癌患者的预后.

Abstract

Objective To compare the clinicopathologic characteristics and prognosis of esophagus cancer patients between different age groups.Methods Totally 426 cases were divided into youth group (≤45 years old,70) and elderly group (＞ 45 years old,356).The clinical data were collected and analyzed.Results The 5-year and 10-year survival rate were 35.2％ (150/426) and 26.3％ (112/426),respectively.There were no differences in 5-year (37.1％ vs.34.8％,P ＞ 0.05) and 10-year survival rate (30.0％ vs.25.6％,P ＞ 0.05) between youth group and elderly group.However,the percentage of pathologic stage Ⅲ cancer in youth group (51.4％,36/70) was higher than the elderly group (36.5％,130/356),x2 =5.469,P ＜0.05.The without lymphonodus metastasis,the few area number of lymphonodus metastasis,the high differentiated degree had significant impact on survival by Kaplan-Meier (P ＜0.05).Lymphonodus metastasis (x2 =8.110,P ＜ 0.05),the area number of lymphonodus metastasis,(x2 =9.992,P ＜ 0.05),and differentiated degree (x2 =4.468,P ＜ 0.05) were the influence factors of prognostic by Cox regression analysis.Conclusion Although youth esophageal cancer patients have later stage of TNM than elderly patients,the prognosis is comparable to elderly patients.Lymphonodus metastasis,more area number of lymphonodus metastasis,and the higher differentiated degree could weight against the survival.

关键词

食管癌/年龄/病理特征/预后

Key words

Esophagus cancer/Age/Clinicopathologic characteristics/Prognosis

引用本文复制引用

出版年

2015
医药论坛杂志
中华预防医学会，河南省医学情报研究所

医药论坛杂志

影响因子：0.47
ISSN：1672-3422
被引量1
参考文献量3
段落导航相关论文