Correlation between serum LOXL2 and recurrence of atrial fibrillation after radiofrequency ablation
Objective To explore the predictive value of serum LOXL2 for recurrence of atrial fibrillation(AF)after ra-diofrequency ablation.Methods A total of 173 patients with atrial fibrillation who underwent radiofrequency ablation for the first time were enrolled.According to whether atrial fibrillation recurred during the follow-up period,the patients were divided into two groups:recurrence group and non-recurrence group.The differences of clinical pathological data and serum LOXL2 between recurrence group and non-recurrence group were compared,and the correlation analysis and multivariate logistic regression analysis were carried out to find out the predictive factors of recurrence of atrial fibril-lation.Results There were 94 males with an average age of(66.3±7)years.After 6 months of follow-up,a total of 62 patients had recurrence of atrial fibrillation.The level of serum LOXL2 in patients with recurrent AF was significantly higher than that in patients without recurrence,and was correlated with body mass index,CHA2DS2-VASC score,left atrial diameter(LAD),BNP,hs-CRP and TGF-β.It was positively correlated with LVEF and negatively correlated with LVEF(all P＜0.05).ROC curve showed that serum LOXL2＞470.94 ng/mL was the best threshold for recurrence of atri-al fibrillation.The sensitivity and specificity were 85.5％and 68.5％,respectively.Multivariate logistic regression analysis showed that serum LOXL2 was an independent predictor of AF recurrence after radiofrequency ablation(OR=1.014,95％CI:1.008-1.021,P＜0.001).The higher the level of LOXL2,the higher the risk of AF recurrence.Conclusion The level of serum LOXL2 is higher in patients with recurrent atrial fibrillation,which is an independent risk factor for recurrence of atrial fibrillation after radiofrequency ablation.
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