Clinical study of different concentrations of ozone macroautoblood therapy on patients with rheumatoid arthritis
Objective To investigate the effect of different concentrations of ozone macroautoblood therapy on patients with rheumatoid arthritis(RA).Methods Ninety patients with RA admitted to Zhengzhou People's Hospital from From June 2022 to June 2023 were selected and divided into methotrexate group(treated with methotrexate tablets),low-concentration ozone group(treated with 30 μg/mL ozone combined with methotrexate)and high-concentration ozone group(treated with 50 μg/mL ozone combined with metho-trexate)by random number table method,with 30 cases in each group.After 4 and 12 weeks of treatment,clinical effi-cacy,health status[health assessment questionnaire(HAQ)],pain degree[visual analog scale(VAS)],disease ac-tivity[28 joint disease activity index(DAS28)],inflammatory factors[erythrocyte precipitation rate(ESR),C-reac-tive protein(CRP),and tumor necrosis factor-α(TNF-α),interleukin(IL)-6,1L-10,IL-17]and immune function indicators[rheumatoid factor(RF),serum anti-cyclic citrullinated peptide antibody(anti-CCP),immuno-globulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)levels]were compared between the two groups.Results After 12 weeks of treatment,the total effective rate of the three groups was significantly different(P＜0.05),and the total effective rate of the high concentration ozone group was significantly higher than that of the low concentration ozone group and methotrexate group(P＜0.05).After 4 and 12 weeks of treatment,the HAQ score,VAS score and DAS28 score in the three groups showed a gradually decreasing trend,and the difference was significant among the three groups at the same time point(P＜0.05),and the HAQ score,VAS score and DAS28 score in the high concentration ozone group were significantly lower than those in the low concentration ozone group and methotrexate group(P＜0.05).After 4 and 12 weeks of treatment,the levels of ESR,serum levels of CRP,TNF-α,IL-6,IL-10 and IL-17 in the three groups showed a gradually decreasing trend,and the difference was significant(P＜0.05).ESR,serum levels of CRP,TNF-α,IL-6,IL-10 and IL-17 in high concentration ozone group were significantly lower than those in low concentration ozone group and methotrexate group(P＜0.05).After 4 and 12 weeks of treatment,the levels of RF,anti-CCP,IgA,IgG and IgM in the three groups were gradually decreased,and the differences were significant among the three groups at the same time point(P＜0.05),and the levels of RF,anti-CCP,IgA,IgG and IgM in the high concentration ozone group were significantly lower than those in the low concentration ozone group and methotrexate group(P＜0.05).During treatment,there was no significant difference in the incidence of adverse reactions among the three groups(P＞0.05).Conclusion Compared with methotrexate alone and low concentration(30 μg/mL)ozone group,high concentration(50 pg/mL)ozone macroautoblood therapy is more effective in the treatment of RA,which can re-duce the inflammatory response of patients,enhance immune function,further reduce the pain degree of patients,reduce disease activity,and improve the health status of patients.
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