Expressions of serum MCP-1,BDNF and VIP in patients with endometriosis and their relationship with pain symptoms and disease severity
Objective To observe the expressions of serum macrophage chemotactic protein-1(MCP-1),brain-de-rived neurotrophic factor(BDNF)and vasoactive intestinal peptide(VIP)in patients with endometriosis and their rela-tionship with pain symptoms and disease severity.Methods The clinical data of 106 patients with endometriosis admit-ted to Zhengzhou People's Hospital from August 2019 to August 2022 were retrospectively analyzed,and the patients were classified as endometriosis group.106 healthy women with physical examination were selected as controls during the same period and classified as healthy group.Serum levels of MCP-1,BDNF and VIP were compared between the two groups.According to the pain symptoms of the patients in endometriosis group,they were divided into low-level pain subgroup and high-level pain subgroup,and the levels of serum MCP-1,BDNF and VIP were compared between the two subgroups.The patients in endometriosis group were divided into mild disease subgroup,moderate disease subgroup and severe disease subgroup,and serum MCP-1,BDNF and VIP levels were compared among the three subgroups.The correlation between serum MCP-1,BDNF and VIP levels and pain symptoms and disease severity of patients with endometriosis were analyzed.Results The levels of serum MCP-1,BDNF and VIP with[(242.78±66.71)pg/mL,(207.99±54.03)mg/L,(45.71±8.92)ng/L]in endometriosis group were higher than[(131.65±49.16)pg/mL,(124.17±37.04)mg/L,(22.34±5.19)ng/L]in healthy group(P＜0.05).Serum levels of MCP-1,BDNF and VIP with[(277.15±56.68)pg/mL,(224.52±45.20)mg/L,(50.25±7.66)ng/L]in high-level pain sub-group were higher than[(218.38±51.36)pg/mL,(196.26±42.64)mg/L,(42.49±7.15)ng/L]in low-level pain subgroup,and serum levels of MCP-1,BDNF and VIP with[(297.25±53.05)pg/mL,(240.13±43.06)mg/L,(51.89±7.24)ng/L]in severe disease subgroup were higher than[(251.13±49.16)pg/mL,(213.49± 38.72)mg/L,(47.11±8.03)ng/L]in moderate disease subgroup and[(207.76±42.51)pg/mL,(186.92± 47.98)mg/L,(41.41±8.44)ng/L]in mild disease subgroup,and serum levels of MCP-1,BDNF and VIP in moderate disease subgroup were higher than those in mild disease subgroup(P＜0.05).The levels of serum MCP-1,BDNF and VIP in patients with endometriosis were positively correlated with pain symptoms and disease severity(P＜0.05).Conclusion Serum MCP-1,BDNF and VIP are highly expressed in patients with endometriosis,and they are closely related to pain symptoms and disease severity.The higher the levels of serum MCP-1,BDNF and VIP are,the more serious the pain symptoms and disease condition of patients.The above indicators can be used as effective indicators to evaluate the disease condition of patients.
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