摘要
目的 观察丙卡特罗联合孟鲁司特钠(MK)对小儿支气管哮喘(BA)患者肺功能、气道炎症水平及血清过氧化脂质/过氧化物酶(LPO)水平的影响.方法 选择2021年1月-2022年12月河南中医药大学人民医院收治的150例BA患儿,对照组75例给予常规对症治疗与丙卡特罗,研究组75例在对照组基础上给予MK.比较两组的肺功能、气道反应性指标、气道炎症指标、不良反应,并检测血清LPO、嗜酸粒细胞阳离子蛋白(ECP)、白细胞介素-13(IL-13)水平.结果 治疗后,2组的一秒用力呼吸容积(FEV1)、FEV1/用力肺活量(FVC)、最大呼气峰流速(PEF)、最大呼气中段流量(MMEF)、50％用力呼气流速(FEF50％)、FEF75％均大于治疗前(P＜0.05),且研究组大于对照组(P＜0.05).治疗后,2组的痰液嗜酸性粒细胞(Eos)计数、呼出气一氧化氮(FeNO)、LPO、ECP、IL-13均小于治疗前(P＜0.05),且研究组小于对照组(P＜0.05).研究组不良反应总发生率(22.67％,17/75)较对照组(20.00％,15/75)差异无统计学意义(P＞0.05).结论 丙卡特罗联合MK能改善小儿BA患者肺功能、气道反应性指标,缓解气道炎症,降低血清LPO、ECP、IL-13水平,且未增加不良反应.
Abstract
Objective To observe the impacts of procaterol combined with montelukast sodium(MK)on lung function,airway inflammation level,and serum lipid peroxide/peroxidase(LPO)level in children with bronchial asthma(BA).Methods A total of 150 children with BA admitted to our hospital from January 2021 to December 2022 were collected.The 75 cases in the control group were treated with routine symptomatic therapy and procaterol,while 75 cases in the study group were treated with MK on the basis of the control group.The lung function,airway reactivity indicators,air-way inflammation indicators,adverse reactions were compared between the two groups,and serum LPO,eosinophil cat-ionic protein(ECP),and interleukin-13(IL-13)levels were detected.Results After treatment,the forced expira-tory volume per second(FEV1),FEV1/forced vital capacity(FVC),maximum peak expiratory flow(PEF),maximum middle expiratory flow(MMEF),50％forced expiratory flow(FEF50％),and FEF75％in both groups were greater than those before treatment(P＜0.05),and the study group were greater than the control group(P＜0.05).After treatment,the count of eosinophils(Eos)in sputum,exhaled nitric oxide(FeNO),LPO,ECP,and IL-13 in both groups were lower than that of before treatment(P＜0.05),and the study group were lower than the control group(P＜0.05).There was no statistically obvious difference in the total incidence of adverse reactions between the study group(22.67％,17/75)and the control group(20.00％,15/75)(P＞0.05).Conclusion The combination of pro-caterol and MK can improve lung function,airway reactivity indicators,alleviate airway inflammation,reduce serum LPO,ECP,and IL-13 levels in pediatric BA patients,and not increase adverse reactions.
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