Impacts of procaterol combined with montelukast sodium on lung function,airway inflammation level and serum LPO level in children with bronchial asthma
Objective To observe the impacts of procaterol combined with montelukast sodium(MK)on lung function,airway inflammation level,and serum lipid peroxide/peroxidase(LPO)level in children with bronchial asthma(BA).Methods A total of 150 children with BA admitted to our hospital from January 2021 to December 2022 were collected.The 75 cases in the control group were treated with routine symptomatic therapy and procaterol,while 75 cases in the study group were treated with MK on the basis of the control group.The lung function,airway reactivity indicators,air-way inflammation indicators,adverse reactions were compared between the two groups,and serum LPO,eosinophil cat-ionic protein(ECP),and interleukin-13(IL-13)levels were detected.Results After treatment,the forced expira-tory volume per second(FEV1),FEV1/forced vital capacity(FVC),maximum peak expiratory flow(PEF),maximum middle expiratory flow(MMEF),50％forced expiratory flow(FEF50％),and FEF75％in both groups were greater than those before treatment(P＜0.05),and the study group were greater than the control group(P＜0.05).After treatment,the count of eosinophils(Eos)in sputum,exhaled nitric oxide(FeNO),LPO,ECP,and IL-13 in both groups were lower than that of before treatment(P＜0.05),and the study group were lower than the control group(P＜0.05).There was no statistically obvious difference in the total incidence of adverse reactions between the study group(22.67％,17/75)and the control group(20.00％,15/75)(P＞0.05).Conclusion The combination of pro-caterol and MK can improve lung function,airway reactivity indicators,alleviate airway inflammation,reduce serum LPO,ECP,and IL-13 levels in pediatric BA patients,and not increase adverse reactions.
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