Clinical effect of low molecular weight heparin calcium injection combined with prednisone in the treatment of nephrotic syndrome in children
Objective To study the clinical efficacy of low molecular weight heparin calcium combined with prednisone in the treatment of children with nephrotic syndrome.Methods The research object of 72 children with nephrotic syn-drome admitted to Anyang peoples Hospital from August 2021 to August 2022,were retrospectively analyzed,on the ba-sis of treatment were divided into two groups,the control group(n=35)using prednisone treatment,the observation group(n=37)using low molecular heparin calcium injection and combination treatment with prednisone,the clinical efficacy of the two groups was compared,and the improvement of renal function and coagulation function of the two groups was observed.Results The total effective rate of the observation group was 94.59％,which was significantly higher than that of the control group(77.14％)(P＜0.05).There was no significant difference in urea nitrogen(BUN),blood creatinine(Scr),creatinine clearance(Ccr)and 24 h urinary protein quantitative level between the two groups before treatment(P＞0.05),and both groups were significantly reduced after treatment.BUN,Scr,Ccr and 24 h urinary protein quantitative levels in observation group were(7.02±0.53)mmol/L,(75.19±6.08)μmol/L,(65.10±4.69)mL/min and(0.87±0.21)g,respectively,which were lower than those of control group(P＜0.001).Before treatment,there was no statistical significance in the levels of thromboplastin time(APTT),pro-thrombin time(PT),fibrinogen(FIB),antithrombin Ⅲ(AT-Ⅲ)and D-dimer(D-D)between the two groups(P＞0.05).After treatment,APTT,PT and AT-Ⅲ were significantly increased,while FIB and D-D were de-creased.The APTT,PT and AT-Ⅲ levels in the observation group were(35.26±5.31)s,(18.26±3.07)s and(106.82±8.14)g/L,respectively,which were higher than those in the control group,and the FIB and D-D levels were(3.07±0.45)g/L and(0.34±0.09)mg/L,respectively.All comparisons between groups were P＜0.001.Conclusion Low molecular weight heparin calcium injection combined with prednisone has significant clinical efficacy in the treatment of children with nephrotic syndrome,which can effectively improve coagulation and renal function in children,and has the value of promotion.
Low molecular weight heparin calcium injectionPrednisoneNephrotic syndrome in childrenClinical effectRenal functionBlood coagulation function
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