Diagnostic value and significance of serum CCL22,IL-6 and Eotaxin-3 in thyroid carcinoma
Objective To investigate the serum levels of CC-like chemokines 22(CCL22),interleukin-6(IL-6)and eosinophilic chemoattractant phthalein 3(Eotaxin-3)in patients with thyroid cancer,and to analyze their diagnos-tic value for thyroid cancer.Methods A total of 86 patients with thyroid cancer admitted to our hospital from March 2020 to July 2022 were selected as the study group,58 patients with thyroid adenoma admitted to our hospital during the same period were selected as the control group,and 48 healthy volunteers during physical examination were selected as the healthy group.Serum levels of CCL22,IL-6 and Eotaxin-3 were compared among all groups.The diagnostic val-ue of serum indexes for thyroid cancer was analyzed by ROC.The relationship between the serum levels of each index and the expression levels of invasion gene[CXCR4 receptor 4,depolymerizing metalloproteinase 9(ADAM9)]and pro-liferating gene[Xklp2 target protein(TPX2)]was analyzed.The correlation between the levels of serum indexes and clinicopathologic features and the expression levels of invasion genes and proliferative genes was analyzed.Results The serum levels of CCL22,IL-6 and Eotaxin-3 in the study group were higher than those in the control group and the healthy group,and the control group was higher than the healthy group(P＜0.05).The AUC of serum CCL22,IL-6,Eotaxin-3 combined diagnosis of thyroid cancer was higher than that of single diagnosis(P＜0.05).Serum CCL22,IL-6 and Eotaxin-3 were negatively correlated with the degree of differentiation,and positively correlated with lymph node metastasis,capsule invasion,TNM stage and mRNA expression levels of TPX2,CXCR4 and ADAM9(P＜0.05).Conclusion Serum levels of CCL22,IL-6 and Eotaxin-3 in patients with thyroid cancer are increased,which are closely related to clinicopathological features and malignancy degree of tumor.Combined detection of CCL22,IL-6 and eotaxin-3 levels is of certain diagnostic value for thyroid cancer.
Thyroid carcinomaCC chemokines 22Interleukin-6Eosinophil chemoattractant phthalein 3Diagnostic value
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