卡前列素氨丁三醇联合垂体后叶素和缩宫素对胎盘早剥产后大出血的疗效
Effects of pituitrin combined with carprost ambutritol and oxytocin on postpartum hemorrhage after placental abruption
石杨磊1
作者信息
- 1. 平顶山市第一人民医院药学部,河南平顶山 467000
- 折叠
摘要
目的 分析胎盘早剥产后大出血产妇应用垂体后叶素、卡前列素氨丁三醇、缩宫素治疗的效果.方法 以平顶山市第一人民医院2019年5月至2021年5月收治的64例胎盘早剥产后大出血产妇为研究对象,以随机数字表法分组,对照组32例应用卡前列素氨丁三醇联合缩宫素治疗,研究组32例在对照组的基础上加用垂体后叶素治疗,对比两组患者治疗效果、产后出血量、止血时间、凝血功能指标变化情况、妊娠结局、第三产程时间、住院时间、不良反应发生率.结果 研究组与对照组患者治疗总有效率分别为93.75％、75.00％,组间对比差异显著(P＜0.05);研究组患者产后30 min出血量(150.24±18.87)mL、产后2h出血量(202.07± 26.69)mL、产后24 h出血量(281.12±31.16)mL,均少于对照组,止血时间[(25.26±4.88)min]均短于对照组,两组对比差异显著(P＜0.05);治疗后研究组患者TT、APTT、FIB水平分别为(18.13±3.22)s、(40.10± 10.06)s及(3.15±0.71)g/mL,均显著低于对照组,两组对比差异显著(P＜0.05);研究组不良妊娠结局发生率(3.13％)低于对照组(18.75％)(P＜0.05);研究组患者第三产程时间(4.41±1.02)min、住院时间(6.62±1.23)d,均少于对照组(P＜0.05);研究组患者药物不良反应发生率(6.25％)显著低于对照组(25.00％)(P＜0.05).结论 对胎盘早剥产后大出血产妇应用垂体后叶素、卡前列素氨丁三醇、缩宫素联合治疗可显著改善其病情,优化妊娠结局,且药物不良反应较少,治疗安全性有保障,此治疗方案值得在临床中推广应用.
Abstract
Objective To analyze the effect of pituitrin,carprost ambutriol and oxytocin in the treatment of postpartum hemorrhage after placental abruption.Methods Totally 64 cases of postpartum hemorrhage after placental abruption ad-mitted to the First People's Hospital of Pingdingshan City from May 2019 to May 2021 were divided into four groups by random number table method.32 cases in the control group were treated with caprost triol combined with oxytocin,and 32 cases in the study group were treated with pituitarine on the basis of the control group.The therapeutic effect,post-partum blood loss,hemostasis time,changes in coagulation function indexes,pregnancy outcome,third stage of labor time,hospital stay and incidence of adverse reactions were compared between the two groups.Results The total effec-tive rate of the study group and the control group was 93.75％and 75.00％,respectively,with significant difference be-tween groups(P＜0.05).The postpartum blood loss in the study group was(150.24±18.87)mL in 30min,(202.07±26.69)mL in 2h and(281.12±31.16)mL in 24h,which were all less than those in the control group,and the hemostasis time[(25.26±4.88)min]was shorter than that in the control group.The difference between the two groups was significant(P＜0.05).After treatment,the levels of TT,APTT and FIB in the study group were(18.13±3.22)s,(40.10±10.06)s and(3.15±0.71)g/mL,respectively,which were significantly lower than those in the control group,and the difference between the two groups was significant(P＜0.05).The incidence of ad-verse pregnancy outcome in the study group(3.13％)was lower than that in the control group(18.75％)(P＜0.05).The time of the third stage of labor in the study group was(4.41±1.02)min and the time of hospitalization was(6.62±1.23)d,which were lower than those in the control group(P＜0.05).The incidence of adverse drug reac-tions in the study group(6.25％)was significantly lower than that in the control group(25.00％)(P＜0.05).Conclusion The combined treatment of pituitrin,carprost ambutritol and oxytocin can significantly improve the condi-tion and optimize the pregnancy outcome of puerpera hemorrhage after placental abruption,and the adverse drug reac-tions are less,the treatment safety is guaranteed,this treatment plan is worth promoting in clinical application.
关键词
胎盘早剥/产后大出血/垂体后叶素/卡前列素氨丁三醇/缩宫素/凝血功能Key words
Placental abruption/Postpartum hemorrhage/Pituitrin/Carprost aminobuttriol/Oxytocin/Blood coagulation function引用本文复制引用
出版年
2024
NETL
NSTL
万方数据