Changes and clinical significance of serum miR-218 and miR-92 levels in patients with liver cancer with different TNM stages
Objective To investigate the changes of serum microRNA-218(miR-218)and microRNA-92(miR-92)levels and their clinical significance in patients with liver cancer with different tumor stages(TNM stages).Methods Totally 246 patients with liver disease admitted to our hospital from March 2020 to March 2023 were selected as the study objects,including 112 patients with liver cancer(liver cancer group),134 patients with benign liver disease(benign liver disease group),and 246 healthy subjects in our hospital during the same period were selected as the control group.Serum miR-218 and miR-92 levels of the three groups were compared,and their correlation with HCC occur-rence and TNM stage was analyzed.Serum levels of the two indicators of HCC patients with different TNM stages were compared,and partial regression analysis was performed to analyze the risk factors of HCC occurrence,ROC analysis was performed to analyze the diagnostic value of combined detection of the two indicators for HCC occurrence,and the risk of HCC occurrence in patients with different levels of the two indicators was analyzed.Results At admission,the serum miR-218 level of the three groups was compared:liver cancer group＜benign liver disease group＜control group,and its level was negatively correlated with the occurrence of liver cancer and the TNM stage of liver cancer;the serum miR-92 level was compared:liver cancer group＞benign liver disease group＞control group,and its level was positively cor-related with the occurrence of liver cancer and TNM stage of liver cancer(P＜0.05).The comparison of miR-218 levels in HCC patients with different TNM stages was as follows:stage Ⅳ＜stage Ⅲ＜stage Ⅱ＜stage Ⅰ,and the comparison of miR-92 levels was as follows:stage Ⅳ＞stage Ⅲ＞stage Ⅱ＞stage Ⅰ(P＜0.05).Serum miR-218 level(＞3.00)was a risk factor for HCC,and miR-92 level(＞0.68)was a protective factor(P＜0.05).The AUC of com-bined diagnosis of liver cancer with serum miR-218 and miR-92 levels was 0.817,and the risk of liver cancer in pa-tients with high levels was 0.389 and 3.004 times that of patients with low levels(P＜0.05).Conclusion The expression of miR-218 is down-regulated and miR-92 is up-regulated in the serum of patients with liver cancer,and the expres-sion levels of both are closely related to the progression of liver disease,the occurrence of liver cancer and the TNM stage of liver cancer.Their combined detection has high diagnostic efficacy for liver cancer,and can provide a reference for clin-ical diagnosis of liver cancer and evaluation of the severity of liver cancer.
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