Relationship between serum α-nuclein and cerebral microhemorrhage and severity in patients with mild acute ischemic stroke
Objective To investigate the relationship between serum α-conuclein and cerebral microhemorrhage and severity in patients with mild acute ischemic stroke.Methods Totally 102 patients with mild acute ischemic stroke ad-mitted to the neurology department of our hospital from April 2021 to August 2022 were selected as the research sub-jects.Based on the magnetic sensitive weighted imaging of the head after admission,the patients were divided into a group of 37 patients without cerebral microbleeds and a group of 65 patients with cerebral microbleeds.At the same time,the cerebral microbleeds group was divided into a low-risk group of 22 patients,a medium risk group of 22 pa-tients,and a high-risk group of 21 patients based on the severity score(NSL)of cerebral microbleeds.Record patient general information and serum α-Cokaryotic protein levels were analyzed using multivariate logistic regression to identi-fy the influencing factors of cerebral microbleeds,and Spearman correlation analysis was performed on serum levels α-The relationship between co nuclear protein and the severity of cerebral microbleeds.Results The age,hypertension,diabetes,long-term alcohol history,previous stroke,hypersensitivity C-reactive protein and serum α-concleitin were higher in the cerebral microhemorrhage group(P＜0.05).logistic regression showed that hypertension,diabetes mellitus,long-term history of alcohol consumption,hypersensitivity C-reactive protein,and serum α-conuclein were risk factors for cerebral microhemorrhage in patients with mild acute ischemic stroke(P＜0.05).Serum α-conuclein in the low-risk group was lower than that in the intermediate-risk group and high-risk group,and serum α-conu-clein in the intermediate-risk group was lower than that in the high-risk group(P＜0.05).Spearman correlation a-nalysis showed that serum α-conuclein was positively correlated with the severity of cerebral microhemorrhage(P＜0.05).Conclusion Serumα-co-nuclein in patients with mild acute ischemic stroke complicated by cerebral microhemorrhage is significantly increased,which is a risk factor for cerebral microhemorrhage in patients with mild a-cute ischemic stroke,and is positively correlated with the severity of cerebral microhemorrhage.
α-conucleinMild acute ischemic strokeMicrohemorrhage in the brainSeverityCorrelation
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