Effects of midazolam on stress response,serum BDNF and S100β levels in elderly patients undergoing orthopedic surgery under general anesthesia
Objective To analyze the effects of midazolam on stress response,serum brain-derived neurotrophic factor(BDNF)and S100β levels in elderly patients undergoing orthopedic surgery under general anesthesia.Methods Totally 111 elderly patients with elective orthopedic surgery under general anesthesia were separated into 56 cases in the control group and 55 cases in the observation group according to the random number table method;Propofol was the main anes-thetic program in the control group,and midazolam was the main anesthetic program in the observation group;The surgi-cal situation,hemodynamics,stress response,serum BDNF and S100β levels were compared between the two groups,and the incidence of anesthesiology-related complications was recorded.Results There were no statistically significant differences in operation time,intraoperative blood loss and total anesthesia duration between the two groups(P＞0.05),but in the observation group,the recovery time was remarkably longer than the other group(P＜0.05);Heart rate(HR)at T2～T4,mean arterial pressure(MAP)at T1～T5 and pulse oxygen saturation(SpO2)at T4 in the observa-tion group were remarkably higher(P＜0.05);The polymorphonuclear neutrophil leukocytes(PMN)and malondialdehyde(MDA)in the observation group were remarkably lower after the surgery,and the activity of superoxide dismutase(SOD)was remarkably higher(P＜0.05);The BDNF in the observation group was higher 1d and 3d after the surgery,and the S100β was lower(P＜0.05);The incidence of adverse reaction was remarkably lower in the obser-vation group(7.27％ vs 21.43％,P＜0.05).Conclusion Compared with Propofol,midazolam can significantly re-duce the stress response,reduce the risk of postoperative cognitive impairment and reduce adverse reactions in elderly patients undergoing orthopedic surgery,and the hemodynamics of midazolam is relatively stable.
NETL
NSTL
万方数据
