Analysis of febrile response to β-lactam antibiotics based on FAERS in a hospital
Objective To analyze the signals of fever response to β-lactam antibiotics in our hospital by using the data-base,and to provide evidence-based basis for clinical nursing of drug fever caused by β-lactam antibiotics.Methods The types of β-lactam antibiotics in our hospital were collected and their instructions were reviewed.The fever reaction reports of these drugs were mined with the help of FAERA database,and the data were descriptively ana-lyzed by reporting odds ratio(ROR)and proportion reporting ratio(PRR).Results There were 20 varieties of β-lac-tam antibiotics in our hospital,of which 5 varieties(penicillin G,benzathine penicillin,amoxicillin,amoxicillin clavu-lanic acid and cefaclor)did not include fever reaction in the instructions.A total of 123142 adverse event reports were retrieved from the FAERS database,including 5275 febrile reactions.The PRR values of penicillins,cephalosporins,and carbapenems were 3.44,3.56,and 3.85,respectively.There was a statistically significant correlation between them.The top five PRR values were cefazoxime(17.06),piperacillin-tazobactam(5.40),meropenem(4.17),ceftriaxone(3.69)and ceftazidime(3.63).Conclusion Different β-lactam antibiotics have different correlation in-tensities with fever reactions,and they are not completely consistent with their instructions.In clinical practice,the i-dentification and nursing of drug-induced fever should be strengthened to ensure the safety of patients.
Beta-lactam antibioticsDrug feverAdverse reactionsFever careFDA Adverse event reporting system
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NSTL
万方数据
