Clinical effect of Qidong Yixin granules in treatment of patients with chronic heart failure
Objective To observe the clinical effect of Qidong Yixin Granules in treatment of patients with chronic heart failure.Methods A total of 240 patients with CHF who were admitted to Fuwai Central China Hospital from January to December 2022 were divided into two groups(120 cases in each group).The control group received western medicine anti-heart failure drugs.The treatment group was combined with Qidong Yixin Granules on the basis of the control group.Patients in two groups were treated and followed up for 12 weeks.The clinical efficacy,cardiac ejection fraction(LVEF),B-type natriuretic peptide(BNP)and other cardiac function indexes,exercise tolerance index 6-minute walking test(6MWD),quality of life index Minnesota heart failure quality of life scale score(MLHFQ)and major adverse cardiovas-cular events(MACE)were compared between the two groups before and after treatment.Results The total effective rates of cardiac function classification and TCM syndrome improvement in the treatment group were 91.45％ and 87.17％,re-spectively,while those in the control group were 82.61％ and 78.26％.The general effective rate of improvement of heart function in the treatment group was significantly higher than those in controls(P＜0.05).After 12 weeks of follow-up,the LVEF and 6MWD of the two groups were higher than basal level,and the BNP level,MLHFQ score and LVEDD level were also lower than basal level(P＜0.05).It is worth noting that the decrease of LVEDD,BNP and MLHFQ in the treatment group was significantly higher than those in controls(P＜0.05).The improvement of exercise tolerance 6MWT and LVEF was significantly better than that of the control group(P＜0.05).There is no significant difference in MACE occur between the two groups(P＞0.05).Conclusion Qidong Yixin Granules combined with western medicine standard treat-ment can further improve the cardiac function and TCM syndrome score of CHF patients,and improve exercise tolerance and quality of life.
Chronic heart failureQidong Yixin GranulesCardiac functionQuality of lifePrognosis
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