Expression of serum pepsinogen Ⅰ,Pepsinogen Ⅱ and gastrin 17 in gastric cancer and the predictive value of combined detection for postoperative recurrence of gastric cancer
Objective To investigate the expression of serum pepsinogen Ⅰ(PGⅠ),pepsinogen Ⅱ(PGⅡ)and gastrin 17(G-17)in gastric cancer and the predictive value of combined detection for postoperative recurrence of gastric canc-er.Methods A total of 116 patients with gastric cancer who received radical surgery in our hospital from January 2019 to March 2022(all completed 1-year follow-up)were selected as the observation group,and 116 healthy subjects in the same period were selected as the control group.According to the recurrence situation one year after surgery,they were divided into two subgroups:recurrence(35 cases)and non-recurrence(81 cases).The preoperative serum lev-els of PGⅠ,PGⅡ and G-17 were compared between the two groups,the serum levels of PGⅠ,PGⅡ and G-17 were compared before the operation of gastric cancer with different pathological parameters,the correlation between the preop-erative serum levels of PGⅠ,PGⅡ and G-17 and the pathological parameters were analyzed,and the serum levels of PGⅠ,PGⅡ and G-17 were compared between patients with recurrent and non-recurrent gastric cancer.To analyze the combined detection value of serum PGⅠ,PGⅡ and G-17 for postoperative recurrence of gastric cancer.Results ① Compared with the control group,the serum PGⅠ level in the observation group was lower before surgery,while the levels of PGⅡ and G-17 were higher(P＜0.05).② Comparison of serum PGⅠ levels before surgery:T1～T2＞T3～T4,stages Ⅰ～Ⅱ＞Ⅲ～Ⅳ,no lymph node metastasis ＞ with lymph node metastasis;Comparison of ser-um PGⅡ and G-17 levels before surgery:T1～T2＜T3～T4,Ⅰ～Ⅱ＜Ⅲ～Ⅳ,no lymph node metastasis＜with lymph node metastasis(P＜0.05).③ Preoperative serum PGⅠ level was negatively correlated with the depth of inva-sion,clinical stage and lymph node metastasis,while serum PGⅡ and G-17 level were positively correlated with the depth of invasion,clinical stage and lymph node metastasis(P＜0.05).④ Compared with the patients without recur-rence,the serum PGⅠ level of patients with recurrence 1 week and 4 weeks after surgery was lower,and the serum PGⅡand G-17 levels were higher(P＜0.05).⑤ At 1 and 4 weeks after surgery,the AUC of serum PGⅠ,PGⅡ and G-17 combined to predict postoperative recurrence was greater than that of each single index detection(P＜0.05).Conclu-sion Serum PGⅠ,PGⅡ,and G-17 are significantly correlated with gastric cancer progression and postoperative recur-rence,and can be used as early warning indicators of recurrence after radical surgery,and the detection of the expres-sion of the three is expected to provide a new strategy for the prediction of postoperative recurrence.
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