A meta-analysis of clinical efficacy of guide phlegm and remove blood stasis in treatment of coronary heart disease complicated with diabetes
Objective This study aims to evaluate the clinical efficacy of guide phlegm and remove blood stasis combined with Western medicine in the treatment of coronary heart disease(CHD)complicated with diabetes.Methods A comput-erized search of databases including China National Knowledge Infrastructure(CNKI),VIP,WANFANG DATA,PubMed,and others were conducted to select clinical randomized controlled trials(RCTs)on the use of guide phlegm and remove blood stasis treating CHD complicated with diabetes from January 2015 to December 2022.The selected literature was subjected to quality assessment,data collection,and meta-analysis using Review Manager 5.4 software.Results A total of 182 relevant articles were retrieved,and ultimately,20 studies involving 1755 patients were included.The meta-anal-ysis results revealed that patients treated with guide phlegm and remove blood stasis combined with Western medicine demonstrated a significantly better cardiac functional efficacy com-pared to the control group receiving Western medicine alone(Relative Risk,RR=5.71,95％Confidence Interval,CI:4.08-7.98,P＜0.00001),with statistically significant differences.The treatment group also showed significant superior-ity in lowering fasting blood glucose(Standardized Mean Difference,SMD=-1.62,95％CI:-1.76 to-1.48,P＜0.00001)and postprandial 2-hour blood glucose(SMD=-1.09,95％CI:-1.25 to-0.93,P＜0.00001)com-pared to the control group.Additionally,in improving lipid profiles,the treatment group exhibited significant advantages over the control group,including total cholesterol(Mean Difference,MD=-1.69,95％CI:-2.56 to-0.82,P=0.0001),triglycerides(MD=-0.85,95％CI:-1.05 to-0.65,P＜0.00001),high-density lipoprotein cholesterol(MD=0.45,95％CI:0.42 to 0.48,P＜0.00001),and low-density lipoprotein cholesterol(MD=-1.04,95％CI:-1.09 to-0.99,P＜0.00001).Moreover,the treatment group outperformed the control group in improving hemorheo-logical parameters,including plasma viscosity(SMD=-0.44,95％CI:-0.72 to-0.16,P=0.002),high shear vis-cosity(SMD=-1.19,95％CI:-1.64 to-0.74,P＜0.00001),and low shear viscosity(SMD=-2.37,95％CI:-3.53 to-1.20,P＜0.0001).Conclusion The combined use of guide phlegm and remove blood stasis with Western medicine demonstrates significant efficacy in improving clinical symptoms,cardiac function,and regulating blood glucose,lipid levels,and reducing blood viscosity in patients with CHD and concomitant diabetes.
Guide phlegm and remove blood stasisCoronary heart diseaseDiabetes mellitusMeta-analysis
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