Relationship between serum CRP/ALB,HCY/HDL-C and NT-proBNP levels and degree of coronary disease in patients with coronary syndrome
Objective To investigate the relationship between serum C-reactive protein/albumin ratio(CRP/ALB),homocysteine/high-density lipoprotein cholesterol ratio(HCY/HDL-C),N-terminal brain natriuretic peptide pre-cursor(NT-proBNP)levels and the degree of coronary artery disease in patients with coronary syndrome.Methods A total of 100 patients who underwent coronary angiography surgery and were diagnosed with CHD in Henan Veterans Hos-pital from January 2021 to May 2023 were included and divided into mild disease group(score＜30),moderate dis-ease group(score 30-60)and severe disease group(score ≥60)according to Gensini scores.The general data,CRP,ALB,HCY,HDL-C and NT-proBNP levels of patients in each group were compared,and CRP/ALB,HCY/HDL-C were calculated to analyze the influencing factors of severe coronary artery lesions,and ROC curves were drawn to analyze the diagnostic efficacy of each factor.Results In the comparison of CRP,CRP/ALB,HCY,HCY/HDL-C and NT-proBNP levels,mild lesion group＜moderate lesion group＜severe lesion group(P＜0.05),but in the comparison of ALB level,mild lesion group＞moderate lesion group＞severe lesion group(P＜0.05).CRP,CRP/ALB,HCY,HCY/HDL-C and NT-proBNP were positively correlated with Gensini integrals(P＜0.05),and ALB was negatively correlated with Gensini integrals(P＜0.05).The levels of CRP,CRP/ALB,HCY,HCY/HDL-C and NT-proBNP were lower in the non-severe disease group those of the severe disease group(P＜0.05),but the level of ALB in the non-severe disease group was higher than those of the severe disease group(P＜0.05).logistic regression analysis found that CRP/ALB,HCY/HDL-C and NT-proBNP were risk factors for severe coronary artery lesions(P＜0.05).The AUC values of CRP/ALB,HCY/HDL-C and NT-proBNP in the diagnosis of severe coronary le-sions were 0.817,0.821 and 0.825,respectively(P＜0.05).Conclusion CRP/ALB,HCY/HDL-C,and NT-proBNP may be risk factors for severe coronary artery lesions in patients with coronary syndrome,and the more severe the coronary artery lesions,the higher the level of CRP/ALB,HCY/HDL-C,and NT-proBNP in patients.
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