Analysis of respiratory atypical pathogen infection in 11 439 febrile patients
Objective To understand the detection rate and infection status of serum atypical pathogen IgM antibodies in patients with fever and respiratory symptoms in Kaifeng area,analyze the epidemiological characteristics of respiratory a-typical pathogens,and provide reference basis for early prevention of respiratory infections and rational use of anti infec-tive drugs in clinical practice.Methods Serum samples from outpatient and inpatient patients with acute respiratory in-fections at Kaifeng Central Hospital from January 2019 to December 2020 were collected.Indirect immunofluorescence assay was used to detect Legionella(LP),Mycoplasma pneumoniae(MP),Chlamydia pneumoniae(CP),adenovirus(ADV),respiratory syncytial virus(RSV),influenza A virus(INFA),influenza B virus(INFB)PIVS and COX,the serum IgM antibodies against nine atypical respiratory pathogens.SPSS 21.0 software was used to statistically analyzed.As a result,serum samples from 11 439 patients with respiratory tract infections were collected.A total of 5 026 cases were tested positive for IgM antibodies against atypical pathogens in respiratory tract infections(hereinafter referred to as the nine test),with a positive rate of 43.9％.The comparison of the positive rates of the obtained antibodies was x2=4419.5,P=0.00.3 472 cases were positive for a single antibody,accounting for 69.1％.1 523 cases were positive for two types of antibodies,accounting for 30.3％.31 cases were pos-itive for three or more types of multiple antibodies,accounting for 0.6％.The comparison of the results was x2=5331.1,P=0.00.The positive rate in 2019 was 42.7％,and in 2020 it was 45.1％.The difference in positive rates between the two years was statistically significant(x2=6.37,P=0.012).Comparison of the positivity rates of nine tests in different age groups:49.4％in the children's group,31.0％in the youth group,32.8％in the middle-aged group,and 42.8％in the elderly group.Comparison of positivity rates(x2=130.7,P=0.00),the difference was sta-tistically significant.The highest proportion of antibodies against nine pathogens in different age groups are:48.3％for Legionella pneumophila and 91.7％for Streptococcus pneumoniae in the elderly group;Chlamydia pneumoniae accoun-ted for 38.2％in the youth group;Among the children,55.6％were positive for Mycoplasma pneumoniae,58.9％were adenovirus,73.1％were respiratory syncytial virus,39.4％were influenza A virus,43.7％were influenza B vi-rus,and 40.1％were parainfluenza virus.Conclusion There is a difference in the positivity rates of IgM antibodies a-gainst nine respiratory pathogens between 2019 and 2020.The main pathogenic atypical pathogens are Mycoplasma pneumoniae,influenza A and B viruses.Among different age groups,children have the highest positivity rate in patho-gen classification,with Mycoplasma pneumoniae being the main pathogen,influenza virus being the main antibody in the elderly,and various types of pathogen infections present in middle-aged and young people,the epidemic time of infec-tion is two peak periods in the northern region,winter and spring.Therefore,according to the characteristics of the pathogen epidemic,targeted prevention and treatment work should be carried out,and anti infective drugs should be used reasonably to effectively shorten the course of the disease and improve the quality of diagnosis and treatment.
Respiratory tract infectionSerum IgM antibodiesAnalysis of atypical pathogens
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