Effects of high throughput hemodialysis on antioxidant effect,micro-inflammatory state and cardiovascular events in elderly patients with diabetic nephropathy
Objective To analyze the effects of high throughput hemodialysis(HFHD)on the antioxidant effect,micro-inflammatory state and cardiovascular events in patients over 60 years old with diabetic nephropathy(DN).Methods The clinical data of 127 patients with DN admitted to our hospital from May 2020 to April 2022 were retro-spectively analyzed.According to age ≥60 years and＜60 years old,they were divided into elderly group(HFHD,n=65)and non-elderly group(HFHD,n=62).The oxidative stress response[oxide dismutase(SOD),malondialde-hyde(MDA)and glutathione peroxidase(GSHPx)],micro-inflammation Factors[Tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6)and hypersensitive C-reactive protein(Hs-CRP)],Renal function[Urea ni-trogen(BUN),creatinine(Scr)],nutritional status[albumin(ALB),proalbumin(PA)and total protein(TP)]and prognosis of different populations were compared using HFHD.Results The SOD,MDA and GSHPx levels of the two groups were significantly increased after treatment,and the SOD,MDA and GSHPx levels in the elderly group were higher than those in the non-elderly group(P＜0.05).The levels of TNF-α,IL-6 and hs-CRP in the two groups were decreased after treatment,and the levels of TNF-α,IL-6 and hs-CRP in in the elderly group were lower than those in the non-elderly group(P＜0.05).BUN,Scr andβ2-MG levels in the two groups were decreased after treatment,and BUN,Scr and β2-MG levels in the elderly group were lower than those in the non-elderly group(P＜0.05).The levels of ALB,PA and TP in the two groups were in-creased after treatment,and the levels of ALB,PA and TP in the elderly group were higher than those in the non-eld-erly group(P＜0.05).During the follow-up period,there was no significant difference in the incidence rates of angi-na pectoris,myocardial infarction,and heart failure between the two groups(P＞0.05).The 1-year survival rate of the non-elderly group was higher than that of the elderly group(P＜0.05).Conclusion HFHD treatment can strengthen the antioxidant effect in elderly diabetic nephropathy patients,and reduce the incidence of cardiovascular e-vents in diabetic nephropathy patients＞60 years old.
High-throughput hemodialysis＞60 years old diabetic nephropathyAntioxidantMicroinflammatory stateCardiovascular event
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