Efficacy and safety of medical oxygen trioxide autohemotherapy combined with diclofenac sodium in treatment of patients with acute gouty arthritis
Objective To explore the efficacy and safety of medical oxygen trioxide autohemotherapy combined with di-clofenac sodium in the treatment of patients with acute gouty arthritis(AGA).Methods Totally 126 AGA patients ad-mitted to Zhengzhou Peoples Hospital from June 2022 to June 2023 were selected as the study subjects.The patients were randomly divided into diclofenac sodium group(treated with diclofenac sodium)and medical oxygen trioxide group(treated with medical oxygen trioxide autohemotherapy and diclofenac sodium),with 63 cases in each group.After 1 week of treatment,the clinical efficacy,joint pain,swelling,limited mobility score,erythrocyte sedimentation rate,TNF-α,IL-6,IL-1 βCRP levels,and adverse reactions were compared between the two groups.Results After 1 week of treatment,the total effective rate of medical oxygen trioxide group was 96.83％,which was significantly higher than that of diclofenac sodium group 79.37％(P＜0.05);The scores of joint pain,swelling and activity limitation in the medical oxygen trioxide group were significantly lower than those in the diclofenac sodium group(P＜0.05);Eryth-rocyte sedimentation rate,TNF-α,IL-6,IL-1 β,CRP levels were significantly lower than those in the diclofenac sodi-um group(P＜0.05);During the treatment,the incidence of adverse reactions in the medical oxygen trioxide group was 12.67％,which was slightly higher than that in the diclofenac sodium group(9.52％),but the difference was not signif-icant between the groups(P＞0.05).Conclusion The medical oxygen trioxide autohemotherapy combined with di-clofenac sodium in treatment of AGA patients has a higher clinical efficacy,which can effectively reduce the degree of joint pain and swelling,improve the patients'limited joint movement,reduce the erythrocyte sedimentation rate,reduce in-flammatory reaction,and does not significantly increase adverse reactions,with a higher safety.
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