Changes and significance of tumor specific growth factor in patients with liver cancer before and after treatment
Objective To explore the changes and significance of levels of vascular endothelial growth factor(VEGF),Glypican-3(GPC3)and tumor specific growth factor(TSGF)in patients with liver cancer before and after transcatheter arterial chemoembolization(TACE)sequential percutaneous microwave ablation(MWA).Methods The clinical data of 532 patients with advanced liver cancer admitted to the First Affiliated Hospital of Zhengzhou University from May 2018 to April 2022 were retrospectively analyzed,and the patients were divided into simple TACE group(TACE alone,n=252)and sequential group(TACE sequential MWA treatment,n=280)according to treatment methods.The postoperative effi-cacy,survival rate and serum levels of VEGF,GPC3 and TSGF before and after surgery were compared between the two groups.Adverse reactions of treatment were recorded,and the predictive value of the above serological indicators on effica-cy of TACE sequential MWA intervention was analyzed.Results The ORR at 4 weeks after surgery and survival rate at 6 months after surgery in sequential group were higher than those in simple TACE group(P＜0.05).Serum levels of VEGF,GPC3 and TSGF after surgery were lower in sequential group than those in simple TACE group(P＜0.05).The incidence rates of postoperative hepatic pain and needle-tract bleeding in sequential group were higher compared with those in simple TACE group(P＜0.05).The levels of serum VEGF,GPC3 and TSGF in effective subgroup at 4 weeks after surgery were lower than those in ineffective subgroup(P＜0.05).The predictive efficiency of serum VEGF,GPC3 and TSGF alone in the diagnosis of ineffectiveness of TACE sequential MWA in PLC was lower than that of combined diagnosis.Conclusion Serum levels of VEGF,GPC3 and TSGF can guide the efficacy evaluation of TACE sequential MWA in the treatment of PLC.
Liver cancerTranscatheter arterial chemoembolizationSequential percutaneous microwave ablationTumor specific growth factor
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