Guiding value of plasma mixing test combined with thromboelastography in clinical transfusion of HBV patients
Objective To explore the guiding value of plasma mixing test combined with thromboelastography(TEG)and conventional coagulation test(CCT)in clinical blood transfusion in grassroots hospitals.Methods Select 40 pa-tients with hepatitis B(HBV)admitted to our intensive care unit from March 2021 to March 2023 as the study group,Based on the 1∶1 principle,and 40 healthy subjects in our hospital during the same period were selected as the control group.TEG,CCT and platelet count(PLTs)were examined in all subjects.The TEG indexes,CCT indexes and PLTs results[blood coagulation time(K),coagulation reaction time(R),coagulation Angle(Angle),maximum amplitude(MA),and rate of blood clot amplitude reduction within 30 minutes(Ly30);Prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),International Standardized ratio(INR),fibrin degradation products(FDP),prothrombin activity(PTA),fibrinogen(Fig),PLTs]of the two groups were compared;Analyze the correla-tion between TEG indicators,CCT indicators,and PLTs in the study group,compare the abnormal rates of TEG indica-tors,TCC indicators,and PLTs in the study group,and compare the effectiveness of plasma infusion therapy between the corrected and uncorrected groups.Results R,K,PT,APTT,TT,INR,FDP and Fig in the study group were higher than those in the control group,while Angle,MA,CI,PTA and PLTs were lower than those in the control group(P＜0.05).In the study group,PT,APTT and INR were positively correlated with K and R and negatively correlated with MA,PTA was negatively correlated with K and R,PTA,Fig and PLTs were positively correlated with MA,INR was negatively correlated with CI,PTA,Fig and CI were positively correlated,and the abnormal rate of INR was higher than that of R.The abnormal rate of PLTs was higher than that of MA(P＜0.05);the effective rate of plasma infusion therapy in the corrected group was higher than that in the uncorrected group(P＜0.05).Conclusion Plasma mixing test combined with TEG can more accurately reflect the coagulation status of HBV patients,which can help to optimise the blood transfusion protocol,guide the rational use of blood in clinic,and reduce the clinical transfusion inefficiency.
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