Efficacy of open vascular bypass combined with interventional embolization forposterior inferior cerebellar artery aneurysm and its effect on neurological injury factors and prognosis
Objective To investigate the efficacy of open vascular bypass+interventional embolization in the treatment of posterior inferior cerebellar artery aneurysm(PICAA)and its effect on neurological injury factors and prognosis.Methods Eighty-one patients with PICAA admitted to our hospital between March 2019 and October 2022 were se-lected as study subjects and divided into a combined group(41 cases)and an embolization group(40 cases)according to different treatment protocols.The embolization group received interventional embolization and the combination group received open vascular bypass and interventional embolization.The efficacy,prognosis,perioperative indicators[intrao-perative bleeding,length of hospital stay,duration of surgery]and preoperative and 1 d postoperative neurological dam-age factors[neuron-specific enolase(NSE),astroglial-derived protein(S100β)],immune function[CD3+,CD4+,CD4+/CD8+],serum factors[matrix metalloproteinase-9(MMP-9),nuclear factor-κB(NF-κB),in-tercellular adhesion molecule-1(ICAM-1)].Results The combined group had better efficacy than the embolization group,and the GOS score was higher than that of the embolization group(P＜0.05);Compared with the embolization group,the length of hospitalization and duration of surgery were significantly longer in the combined group,and intraoperative bleeding was significantly higher(P＜0.05);serum S100β and NSE levels were slightly higher in the combined group than in the embolization group 1 d after surgery,but there was no significant difference between the two groups(P＞0.05);1 d after surgery CD3+,CD4+and CD4+/CD8+were slightly lower in the combined group than in the embolization group,but the difference was not statistically significant(P＞0.05);Serum MMP-9,ICM A-1 and NF-κB levels were lower in the combined group than in the embolization group 1 d after surgery(P＜0.05).Conclusion Cranial vascular bypass combined with interventional embolization is effective in treating patients with PICAA,which can effectively protect brain nerves and reduce inflammatory response.
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