摘要
目的 探讨烟酸对脑梗死(ACI)患者介入治疗后血流状态、神经功能及预后的影响.方法 选取2021年1月-2022年12月收治的ACI患者86例,随机分为对照组(43例,支架置入术+术后常规治疗)与观察组(43例,给予支架置入术+术后常规治疗+烟酸静脉滴注),比较两组脑血流灌注、神经功能及随访90 d预后情况.结果 观察组治疗后颈总动脉血流速度、颈内动脉血流速度、椎动脉血流速度分别为(52.47±4.59)cm/s、(52.84±3.48)cm/s、(45.78±4.13)cm/s,均大于对照组的(48.86±4.27)cm/s、(49.62±3.26)cm/s、(41.74±3.97)cm/s,颈总动脉阻力指数、颈内动脉阻力指数、椎动脉阻力指数分别为(0.62±0.04)、(0.60± 0.06)、(0.59±0.07),均小于对照组的(0.68±0.07)、(0.65±0.05)、(0.63±0.08)(P＜0.05);治疗后观察组NIHSS 为(6.69±1.15)分,低于对照组的(7.86±1.47)分,BDNF、NGF 分别为(5.27±0.89)μg/L、(146.82± 12.74)μg/L,均高于对照组的(4.32±0.77)μg/L、(133.76±14.27)µg/L(P＜0.05);随访90 d,观察组 mRS 评分为(2.67±0.61)分,低于对照组的(3.17±0.57)分(P＜0.05).结论 术后加用烟酸可提高ACI介入治疗患者脑血流灌注,改善神经功能及短期预后.
Abstract
Objective To investigate the effects of niacin on blood flow status,neurological function and prognosis of pa-tients with cerebral infarction(ACI)after interventional therapy.Methods Totally 86 ACI patients admitted from January 2021 to December 2022were randomly divided into control group(43 cases,stent implantation+conventional postopera-tive treatment)and observation group(43 cases,stent implantation+conventional postoperative treatment+niacin in-travenous infusion).Cerebral blood perfusion,neurological function and prognosis of the two groups were compared after 90 days of follow-up.Results After treatment,the blood flow velocity of common carotid artery,internal carotid artery and vertebral artery in observation group were(52.47±4.59)cm/s,(52.84±3.48)cm/s,(45.78±4.13)cm/s,re-spectively,which were higher than those in control group(48.86±4.27)cm/s,(49.62±3.26)cm/s,(41.74±3.97)cm/s(P＜0.05),The common carotid artery resistance index,internal carotid artery resistance index and vertebral artery resistance index in observation group were(0.62± 0.04),(0.60±0.06)and(0.59±0.07),respectively,which were lower than those in control group(0.68±0.07),(0.65±0.05)and(0.63±0.08)(P＜0.05).After treatment,NIHSS in observation group was(6.69±1.15)points,lower than that in control group(7.86±1.47)points,BDNF,NGF in observation group were(5.27±0.89)μg/L,(146.82±12.74)µg/L,respectively,which were higher than those in control group(4.32±0.77)μg/L,(133.76± 14.27)μg/L(P＜0.05).After 90 days of follow-up,the mRS Score of observation group was(2.67±0.61),which was lower than that in control group(3.17±0.57)(P＜0.05).Conclusion The addition of niacin after surgery can im-prove cerebral blood perfusion,neurological function and short-term prognosis of patients treated with ACI.
基金项目
河南省医学科技攻关计划项目(LHGJ20220676)
NETL
NSTL
万方数据