Effect of niacin on blood flow status,neurological function and prognosis of patients with cerebral infarction after interventional therapy
Objective To investigate the effects of niacin on blood flow status,neurological function and prognosis of pa-tients with cerebral infarction(ACI)after interventional therapy.Methods Totally 86 ACI patients admitted from January 2021 to December 2022were randomly divided into control group(43 cases,stent implantation+conventional postopera-tive treatment)and observation group(43 cases,stent implantation+conventional postoperative treatment+niacin in-travenous infusion).Cerebral blood perfusion,neurological function and prognosis of the two groups were compared after 90 days of follow-up.Results After treatment,the blood flow velocity of common carotid artery,internal carotid artery and vertebral artery in observation group were(52.47±4.59)cm/s,(52.84±3.48)cm/s,(45.78±4.13)cm/s,re-spectively,which were higher than those in control group(48.86±4.27)cm/s,(49.62±3.26)cm/s,(41.74±3.97)cm/s(P＜0.05),The common carotid artery resistance index,internal carotid artery resistance index and vertebral artery resistance index in observation group were(0.62± 0.04),(0.60±0.06)and(0.59±0.07),respectively,which were lower than those in control group(0.68±0.07),(0.65±0.05)and(0.63±0.08)(P＜0.05).After treatment,NIHSS in observation group was(6.69±1.15)points,lower than that in control group(7.86±1.47)points,BDNF,NGF in observation group were(5.27±0.89)μg/L,(146.82±12.74)µg/L,respectively,which were higher than those in control group(4.32±0.77)μg/L,(133.76± 14.27)μg/L(P＜0.05).After 90 days of follow-up,the mRS Score of observation group was(2.67±0.61),which was lower than that in control group(3.17±0.57)(P＜0.05).Conclusion The addition of niacin after surgery can im-prove cerebral blood perfusion,neurological function and short-term prognosis of patients treated with ACI.
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