目的 对血液透析糖尿病肾病患者采用新加肾元汤治疗，分析该治疗方案对其血压、肾功能、肾小球滤过膜通透性及中医症候积分的影响。方法 本文研究对象为南阳市第一人民医院肾病内科收治的糖尿病肾病患者，共110例，其入院时间均为2022年1月-2023年6月，将110例患者按数表法分为各有55例的对照组、观察组，两组均行血液透析治疗，对照组在此基础上采用厄贝沙坦片、利格列汀片治疗，观察组则在对照组的基础上添加新加肾元汤治疗，对两组的氧化应激指标、肾功能、肾小球滤过通透性和中医症候积分进行对比。结果 经统计学分析发现，两组患者治疗后的各项氧化应激指标水平存在明显差异，其中，观察组的血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)水平较高，丙二醛(MDA)水平较低(P＜0。05);在肾功能的比较上，观察组治疗后的尿素氮(BUN)、血肌酐(Scr)均低于对照组(P＜0。05)，两组的血钙(Ca)水平无明显差异;在肾小球滤过通透性的比较上，观察组的血尿酸(UA)、24 h尿蛋白定量(24 h ACR)均低于对照组，肾小球滤过率(eGFR)高于对照组(P＜0。05);在中医症候积分的比较上，观察组治疗后的腰膝酸痛、倦怠乏力、夜尿频多、咽干口燥、气短懒言评分均低于对照组(P＜0。05)。结论 新加肾元汤对血液透析糖尿病肾病患者氧化应激指标、肾功能、肾小球滤过通透性和中医症候积分均具有良好的改善作用。
Study on effect of Xinjia Senyuan decoction on permeability of glomerular filtration membrane in diabetic nephropathy patients on haemodialysis
Objective The patients with diabetic nephropathy on haemodialysis were treated with Xinjia Senyuan decoc-tion,and the effects of this treatment protocol on their blood pressure,renal function,glomerular filtration membrane permeability and Chinese medicine syndrome score were analysed.Methods In this paper,110 patients with diabetic nephropathy admitted to the Department of Nephrology of the First People's Hospital of Nanyang City were studied from January 2022 to June 2023.110 patients were divided into a control group and an observation group of 55 patients each according to the numerical table method,and hemodialysis treatment was performed in the two groups,with Irbesartan and Rigliptin tablets being used for treatment of the control group and Senyuan decoction added on top of the treatment of the control group for comparison of oxidative stress indexes,glomerular filtration permeability and TCM symptom scores of the two groups.In the control group,Irbesartan tablets and Riglitazone tablets were used on the basis of haemodialysis treatment,while in the observation group,Senyuan decoctionwas added on the basis of the control group.Results Sta-tistical analysis revealed that there were significant differences in the levels of various oxidative stress indicators between the two groups of patients after treatment,in which the observation group had higher levels of serum superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX),and lower levels of malondialdehyde(MDA)(P＜0.05);In the comparison of renal function,the urea nitrogen(BUN)and blood creatinine(Scr)levels of the observation group were lower than those of the control group(P＜0.05).In the comparison of renal function,the blood urea nitrogen(BUN)and blood creatinine(Scr)of the observation group were lower than those of the control group(P＜0.05),and the blood calcium(Ca)levels of the two groups were not significantly different;In the comparison of glomerular filtration permeability,the blood uric acid(UA)and 24h urine protein quantitatively(24hACR)of the observation group were lower than that of the control group,and the glomerular filtration rate(eGFR)was higher than that of the control group(P＜0.05);The Chinese medicine symptom scores,the low back and knee pain,tiredness and fatigue,nocturnal uri-nation,dryness of throat and mouth,shortness of breath and slothful speech in observation group were lower than those the control group(P＜0.05).Conclusion Senyuan decoction has good improvement effects on oxidative stress index,renal function,glomerular filtration permeability and Chinese medicine symptom score in haemodialysis diabetic ne-phropathy patients.
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