Predictive value of serum S100β combined with IL-6 in brain injury in patients with emergency sepsis
Objective To analyze the predictive value of serum central nerve specific protein(S100β)combined with interleukin-6(IL-6)in brain injury in patients with emergency sepsis.Methods The serum S100β and IL-6 levels of 107 patients with emergency sepsis admitted to Zhoukou Central Hospital from March 2021 to September 2022 were detected.According to the occurrence of brain injury,107 patients were divided into brain injury group(n=42)and uninjured group(n=65).Cox regression analysis was used to investigate the independent risk factors of brain injury in patients with emergency sepsis,and receiver operating characteristic(ROC)curve was used to analyze the predictive values of serum S100β and IL-6 levels in brain injury in patients with emergency sepsis.Results The levels of serum S100β(0.89±0.17)and IL-6(31.14±4.53)in brain injury group were significantly higher than those in uninjured group(S100β:0.68±0.12;IL-6:20.67±3.18)(P＜0.001).Age ≥55 years old,high APACHE Ⅱ score,high SOFA score,high blood glucose level,high BUN level,high S100β level,and high IL-6 level were independent risk factors for brain injury in emergency sepsis patients(P＜0.05).The AUC of serum S100β combined with IL-6 in pre-dicting brain injury in patients with emergency sepsis was 0.977(P＜0.05),which was higher than that of any index a-lone.When serum S100β level was higher than 0.798 ng/mL and IL-6 level was higher than 25.58 ng/L,there was an increased risk of brain injury in patients with emergency sepsis.Conclusion Serum S100β and IL-6 levels were significantly increased in patients with emergency sepsis brain injury,and serum S100β combined with IL-6 had high predictive value for brain injury in emergency sepsis patients.
SepsisBrain injuryCentral nerve specific proteinInterleukin 6Predictive value
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