Study on correlation between serum CA125 and level of tumor marker CA19-9 and liver metastasis in patients with advanced pancreatic cancer
Objective To analyze the relationship between serum CA125 and CA19-9 tumor marker levels and liv-er metastasis in patients with advanced pancreatic cancer,and to explore the risk factors of pancreatic cancer liver metastasis and the prognostic predictive value of CA125 and CA19-9 for pancreatic cancer liver metastasis.Methods Totally 70 patients with advanced pancreatic cancer admitted from April 2021 to April 2023 were select-ed.All patients were divided into two groups based on whether they had liver metastasis,with 36 cases in the liver metastasis group and 34 cases in the non-liver metastasis group.The content data of tumor markers such as CEA,CA19-9,CA125,CY-FRA21-1,CA72-4 in serum samples of all patients were collected,and logistic regres-sion was used for multifactor regression analysis.Results The increase in the levels of CA19-9 and CA125 in se-rum is correlated with whether liver metastasis occurs in pancreatic cancer(P＜0.05),and can predict the risk of liver metastasis;the levels of CEA,CY-FRA21-1,and CA72-4 increases and decreases are not related to whether liver metastasis occurs in pancreatic cancer(P＞0.05),and the risk of liver metastasis cannot be predic-ted.The average one-year survival rate of patients with high-level liver metastases of CA19-9 and CA125 was 13.89％(5/36),and the average one-year survival rate of patients with low-level non-liver metastases was 23.53％(8/34),which was statistically significant.(P＜0.05).High-level expression of CA19-9 and CA125 is an unfavorable factor for prognosis,and is closely related to the survival time and prognosis of patients with liver metastasis and advanced pancreatic cancer.The specificities of serum CA125,CA19-9 and combined use for pancreatic cancer liver metastasis are:67.7％、58.2％、94.1％,respectively,and the sensitivities are:80.6％、86.1％、80.6％,the joint prediction effectiveness of the two is significantly improved.Conclusion In-creased levels of serum CA125 and CA19-9 are related to liver metastasis of pancreatic cancer and are risk factors for liver metastasis of pancreatic cancer.Increased levels of serum CA1 2-5 and CA19-9 are related to poor prog-nosis of liver metastasis of pancreatic cancer.The predictive efficacy of the combined detection of the two is signifi-cantly improved and is worthy of clinical promotion.
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