Early application value and mechanism of angiotensin receptor enkephalin inhibitors in patients with acute myocardial infarction
Objective To investigate the early application value and mechanism of angiotensin receptor enkephalin in-hibitors in patients with acute myocardial infarction.Methods Totally 122 patients with acute myocardial infarction(AMI)admitted to our hospital from July 2022 to July 2023 were randomly divided into routine group and sacubitril val-sartan sodium tablet(Sak)group,with 61 patients in each group.Both groups received emergency PCI treatment.The conventional group received antiplatelet drugs routinely after surgery,and the Sak group began to take Sak on the 3rd day after surgery.The cardiac function indexes,myocardial injury and myocardial energy metabolism,inflammation level,in-cidence of heart failure,re-hospitalization rate,and mortality were compared between the two groups before and after treatment.Results After 12 weeks of treatment,the left ventricular end-systolic diameter and left ventricular end-di-astolic diameter in Sak group were(47.39±8.11)mm and(50.84±6.93)mm,respectively,which were lower than those in conventional group(54.84±8.49)mm and(58.49 ±5.39)mm,respectively.Left ventricular ejection fraction and 6min walking distance in Sak group were(54.39±4.84)％and(349.28±29.11)m,respectively,higher than those in conventional group(50.03±5.37)％and(324.45±41.03)m(P＜0.05).The energy consumption of tro-ponin I,brain natriuretic peptide and myocardium in Sak group were(0.59±0.32)μg/L,(152.95±98.19)ng/L and(105.82±22.83)Cal/min,respectively.It was lower than(1.33±0.48)μg/L,(349.60±121.63)ng/L,(119.10 ±26.82)Cal/min in conventional group(P＜0.05).Hypersensitive C-reactive protein,tumor necrosis factor-αand procalcitonin in Sak group were(13.37±4.39)ng/mL,(45.29±18.71)ng/L,(0.95±0.32)Cal/min,respec-tively.It was lower than(17.60±3.20)ng/mL,(59.73±19.74)ng/L and(0.31±0.19)Cal/min in conventional group(P＜0.05).The incidence of heart failure and re-hospitalization in Sak group were 3.28％and 4.92％,respec-tively,which were lower than 16.39％and 19.67％in conventional group(P＜0.05).The fatality rate was 4.92％in the conventional group and 1.64％in the Sak group,with no significant difference(P＞0.05).Conclusion Early ap-plication of Sak in patients with AMI can effectively improve cardiac function,reduce myocardial injury,reduce inflamma-tion,prevent heart failure and improve prognosis.
NETL
NSTL
万方数据
