Effects of pentoxifroline injection combined with Ezetimibe on neurological impairment and serum levels of Hcy and LDL-C in convalescent cerebral infarction patients
Objective To analyze the effects of injection of pentoxifylline combined with ezetimibe on neurological defi-cits and serum homocysteine(Hcy)and low-density lipoprotein(LDL)levels in recovered patients with cerebral in-farction(CI).Methods From November 2018 to November 2022,314 patients with cerebral infarction(CI)in Zhuma-dian Central Hospital were randomly divided into control group and combination group,with 157 patients in each group.The control group was treated with ezetimibe tablets,while the combination group was treated with injection of pentoxifyl-line and ezetimibe tablets.Clinical efficacy between two groups,National Institutes of Health Stroke Scale(NIHSS),Barthel Index Rating Scale(BI),Mini State of Intelligence Scale(MMSE),hemorheological indicators[low blood vis-cosity(LBV),hematocrit(HCT),plasma viscosity(PV),high blood viscosity(HBV)],serum Hey,LDL-C levels Neuron specific enolase(NSE)levels,including S-100 protein(S100B),brain-derived neurotrophic factor(BD-NF),and neuron specific enolase were compared.Results The total effective rate of combined group was 88.54％,which was higher than that of control group(79.62％)(P＜0.05).There was no significant difference in NIHSS,BI and MMSE scores between the two groups before treatment(P＞0.05).After treatment,the BI and MMSE scores of the combined group were(79.32±6.96)and(25.31±2.71),which were higher than those of the control group(P＜0.05).The NIHSS score of the combined group was(9.38±1.23),which was lower than that of the control group(12.28±1.37)(P＜0.05).There was no significant difference in HBV,PV,HCT and LBV between the two groups before treatment(P＞0.05),and the combined group after treatment was(4.13±0.56)mPa/s,(1.23±0.18)mPa/s,(41.37±6.62)％and(7.65±2.53)mPa/s.It was lower than that of control group(P＜0.05).There was no significant difference in Hcy and LDL levels between the two groups before treatment(P＞0.05).After treatment,the Hey and LDL levels in the combination group were lower than those in the control group(P＜0.05)at(19.35±3.54)mPa/s and(2.95±0.62)mPa/s.There was no significant difference in S100B,BDNF and NSE levels between the two groups before treatment(P＞0.05).After treatment,the S100B and NSE levels in the combination group were lower than those in the control group(P＜0.05)(0.87±0.26 mg/L and 7.35±1.82 ng/mL).After treatment,the level of BDNF in combination group was(8.72±0.91)ng/mL,which was higher than that in control group(6.81±0.83)ng/mL(P＜0.05).Conclusion In the convalescent period of CI patients,pentoxifroline injection combined with ezetimibe has a significant effect,which can inhibit thrombosis,promote blood circulation,nerve repair,improve cognitive function and enhance patients'ability of daily life.
Pentoxifylline for injectionCerebral infarctionNerve functionLow density lipoproteinBlood homocys-teine
NETL
NSTL
万方数据
