Evaluation value of magnetic resonance T1-mapping in risk stratification of hypertrophic cardiomyopathy and its association with poor prognosis
Objective To evaluate the risk stratification and prognosis of hypertrophic cardiomyopathy by quantitative MRI segmental relaxation time imaging(T1-mapping),in order to provide reference for early clinical intervention.Methods A total of 86 patients with hypertrophic cardiomyopathy treated in our hospital from August 2020 to August 2022 were selected as the study group.Risk stratification was assessed according to the left ventricular wall thickness.Another 50 healthy subjects were selected as the control group.Quantitative parameters of magnetic resonance T1-map-ping[initial T1-mapping value,enhanced T1-mapping value,extracellular volume(ECV)value],left ventricular function parameters[left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV)and stroke output were compared between the two groups and different risk groups(SV),left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume index(LVESVI),left ventricular end-systolic volume index(LVED-VI)],to analyze the correlation between quantitative parameters of magnetic resonance T1-mapping and risk stratifica-tion of hypertrophic cardiomyopathy.After 6 months of follow-up,Quantitative parameters of magnetic resonance T1-mapping were compared in patients with different prognostic outcomes;and their predictive value for poor prognosis was analyzed.Results Compared with the control group;the initial T1-mapping value and ECV of the research group were higher(P＜0.05).Compared with mild to moderate patients;the initial T1-mapping value and ECV of severe patients were higher(P＜0.05).Compared with mild-moderate patients;LVESV and SV and LVEF were lower in severe pa-tients(P＜0.05).Initial T1-mapping value and ECV were positively correlated with risk stratification;SV and LVESV;but negatively correlated with LVESV(P＜0.05).Compared with patients with good prognosis;the initial T1-mapping value and ECV of patients with poor prognosis were higher(P＜0.05).The AUC of initial T1-mapping and ECV for poor prognosis of hypertrophic cardiomyopathy were 0.795 and 0.856;respectively;and the AUC of com-bined prediction was 0.927;which was better than that of single parameter prediction.Conclusion Cardiac magnetic resonance T1-mapping technique has a high evaluation value for hypertrophic cardiomyopathy;which can provide refer-ence for early clinical risk stratification and prognosis prediction;so as to carry out targeted follow-up treatment and im-prove prognosis.
Magnetic resonance T1-mapping technologyHypertrophic cardiomyopathyRisk stratificationPrognosis assessment
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