Correlation between serum Lp(a)and apoB/apoA-1 and coronary stenosis inpatients with ST-segment depression
Objective To investigate the predictive value of Lp(a)and apoB/apoA-1 in the severity of coronary artery lesions inpatients with ST-segment depression.Methods A retrospective analysis was performed for 163 patients com-bined with ST-segment depression with electrocardiogram(ECG)from January 2020 to June 2023 who were hospital-ized in the Department of Cardiovascular Medicine of Wuhanthe 4th Hospital and underwent coronary angiography.Dur-ing the same period,70 patients with non-coronary heart disease and no abnormal ECG were selected as the control group.According to the results of coronary angiography,the experimental group was divided into three groups:mild,moderate and severe,and the clinical data of the three groups were compared.Binary multivariate logistics regression a-nalysis was used to analyze the independent risk factors of patients with moderate to severe disease.The receiver operat-ing characteristic(ROC)curve was plotted to analyze the diagnostic value of Lp(a)and apoB/apoA-1 ratios inpa-tients with moderate to severe disease.Results ①There were statistically significant differences in age,history of hyper-tension,Lp(a),UA,apoB,apoA-1,ratio,LDL-C,TG between the experimental group and the control group(P＜0.05).② One-way ANOVA was used for the normal distribution and the homogeneity of the variance was used for the group,and the non-parametric test was used for the non-parametric test,and the results showed that there were statistically significant differences in age,diabetes history,Lp(a),apoB,apoA-1,apoB/apoA-1 ratio,TC and TG lev-els among different groups.Among them,the Lp(a)and ApoB/ApoA-1 ratios showed mild stenosis＜moderate steno-sis＜severe stenosis.③ The patients with ST-segment depression were divided into mild stenosis and moderate to se-vere stenosis groups,and the differences between the two groups were analyzed by binary multivariate logistics regression,and the results showed that Lp(a)and apoB/apoA-1 were independent influencing factors affecting the degree of coro-nary art.④ ROC curve analysis showed that Lp(a)and apoB/apoA-1 had high value in the diagnosis of moderate to severe stenosis lesions inpatients with ST depression,with the AUC of Lp(a)and apoB/apoA-1 being 0.818 and 0.862,the sensitivity being 0.670 and 0.825,the specificity being 0.879 and 0.758(P＜0.001),and the correspond-ing values of Youden index being 24.50 and 0.785,respectively.Conclusion Lp(a)and apoB/apoA-1 have certain diagnostic and predictive value for coronary artery lesions inpatients with ST-segment depression,and provide a simple,economical and new diagnosis and treatment strategy for the clinical diagnosis of coronary atherosclerosis.
Coronary artery lesionsLipoprotein aapoB/apoA-1 ratio
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