Application of multimodal exercise in management of frailty among early to mid-stage gastric adenocarcinoma patients:a randomized controlled trial
Objective This study aimed to evaluate the effectiveness of multimodal exercise in patients with frailty relat-ed to early to mid-stage gastric adenocarcinoma,focusing on its impact on physiological indicators,functional tests,and healthcare expenditures.Methods This study is a randomized controlled clinical experiment.Totally 140 patients with early and middle stage gastric cancer who were admitted to Henan Provincial Cancer Hospital from January 2020 to January 2021 and complicated with frailty or pre-failure after surgery were selected.The control group received health education interventions,while the experimental group underwent a 12-month multimodal exercise intervention.Follow-ups were conducted at baseline,and at the 3rd,6th,9th,and 12th months,assessing physiological indicators(total body water,fat mass,fat-free mass,basal metabolic rate,and body mass index)and functional tests(grip strength,sit-to-stand test,walking test,and six-minute walk test).Results At baseline,there were no significant differ-ences between the control and experimental groups in physiological indicators and functional tests(P＞0.05).Over time,the experimental group showed lower levels of total body water,fat mass,and bmi,but higher levels of fat-free mass,basal metabolic rate,and phase angle compared to the control group(P＜0.05).In terms of functional tests,the experimental group demonstrated higher levels in grip strength,sit-to-stand test,and six-minute walk test,but low-er in the walking test(P＜0.05).The experimental group experienced higher rates of muscle pain and fatigue,but low-er rates of psychological stress(P＜0.05).Regarding healthcare expenditures,the experimental group incurred lower costs in consolidated payments compared to the control group(P＜0.05).Conclusion The application of multimodal exercise in patients with frailty related to early to mid-stage gastric adenocarcinoma can improve physiological indicators and functional test performance,despite potential minor adverse reactions such as muscle pain and fatigue.Additionally,this intervention may contribute to reduced healthcare expenditures.These findings support the effectiveness and feasibil-ity of multimodal exercise as a rehabilitation intervention for patients with early to mid-stage gastric adenocarcinoma.
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